摘要
目的了解结核性胸膜炎患者结核分枝杆菌的耐药情况,为指导临床制定合理化疗方案提供科学依据。方法采用胸膜活检技术获取胸膜组织接种在改良罗氏培养基内进行结核分枝杆菌的培养及药物敏感性测定。结果306例结核性胸膜炎胸膜组织结核分枝杆菌培养阳性者187例,阳性率61.1%。187例药敏测定结果对6种抗结核药物均敏感者148例,敏感率79.1%;耐药39例,耐药率20.9%。结论结核性胸膜炎与肺结核都同样存在着初始耐药性和继发耐药性的问题,同样必须高度重视其化疗原则和管理水平。
Objective To determine the proportion of drug-resistant Mycobacterium tuberculosis in patients with tuberculosis pleurisy.Methods A pleural biopsy was performed for 187 patients with tuberculous pleurisy by Cope needle.The specimens obtained were cultured in modified Lowenstein-Jensen culture medium and the M.tuberculosis isolates were tested for drug resistance.Results Among the pleural biopsy specimens from 306 tuberculous pleurisy patients,187（61.1%） were M.tuberculosis culture positive.Drug susceptibility testing of 187 culture-positive isolates showed 148（79.1%） were susceptible to all drugs,while 39（20.9%） were resistant to at least one drug.Conclusions High prevalences of initial and acquired drug resistance exist in those patients.This study confirms the importance of strict screening and programmatic management in patients with tuberculous pleurisy.
出处
《国际呼吸杂志》
2007年第23期1770-1771,共2页
International Journal of Respiration
关键词
胸膜炎
结核分枝杆菌
药敏测定
Pleurisy
Mycobacterium tuberculosis
Drug susceptibility testing
