摘要
近来的研究表明活化蛋白C（APC）在感染中毒症中具有抗凝、促纤溶和抗炎作用。重组人活化蛋白C（rhAPC）可显著降低感染中毒症患者的病死率。但rhAPC在临床应用中的适应证及其有效性仍存在争议。细胞学研究提示APC可通过与细胞表面受体结合,激活细胞内的各种蛋白酶,使其磷酸化或去磷酸化,诱导细胞内信号转导,调节炎症相关基因的表达,从而调节参与感染中毒症的多个重要病理生理过程。此外,APC可能对感染中毒症所致急性肺损伤起到保护性作用。
Recent studies showed that activated protein C（APC） has anticoagulation,profibrinolysis and anti-inflammation effects in sepsis.Recombinant human activated protein C（rhAPC） significantly reduced the mortality of sepsis patients.However,there was controversy about rhAPC in its clinical indication and effectiveness.Cytological studies suggested that APC can regulate several important pathophysiologic processes of sepsis through combinating to cell surface receptor,activating several proteases in cell plasma,inducing intra-cellular signal transduction,regulating the expression of genes associated with inflammation.Moreover,APC may have a protective effect in sepsis induced acute lung injury.
出处
《国际呼吸杂志》
2007年第23期1805-1810,共6页
International Journal of Respiration
关键词
感染中毒症
急性肺损伤
凝血
抗凝
纤溶
活化蛋白C
Sepsis
Acute lung injury
Coagulation
Anticoagulation
Fibrinolysis
Activated protein C
