摘要
辅助性T细胞17(T helper 17 cell,Th17)是一种新发现的与白细胞介素23(interleukin23,IL-23)相关的、能够分泌IL-17的T细胞亚群,它在分化过程和生物学功能等方面与Th1和Th2以及Treg细胞亚群均有不同之处。转化生长因子β1(transforming growth factorβ1,TGF-β1)和IL-6以及IL-23在Th17细胞的分化形成过程中起着积极的促进作用,而γ干扰素(interferonγ,IFN-γ)和IL-4以及Socs3(suppressor of cytokine signaling 3)蛋白则能抑制它的分化。Th17细胞能参与前炎症反应,同时也能诱使自身免疫病的发生。
Th17（T helper 17 cell） ,a newly discovered subset of T cells is associated with IL-23 and characterized by production of IL-17,the functions of which are distinct from those of Th1, Th2 and Treg subsets. The development of Th17 cells can be promoted by TGF-β1,IL-6,and IL -23. but inhibited by IFN-γ,IL-4 and Socs3. It is clear that Th17 cells have protective effects on body by facilitating the pro-inflammatory responses. On the other hand,the role of Th17 cells in the pathophysiology of autoimmune diseases has been described.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2007年第6期620-625,共6页
Journal of Zhejiang University(Medical Sciences)
基金
浙江大学第九期SRTP资助项目
