摘要
目的：探讨氟骨症患者体内氟蓄积与骨畸形程度的相关性研究。方法：暴露组在内蒙古呼和浩特市托县饮水氟含量高于正常的5个自然村随机选取确诊的氟骨症患者70例。并根据《地方性氟骨症临床分度》进行分度。对照组：在呼和浩特市郊区长期居住的，饮水含氟量正常的人群中随机选取70例。两组人群要求年龄在25～55岁，无其他疾病史者。检测两组血Ca^2＋、P^3＋、Mg^2＋和ALP及血脂TC、TG指标，并用T检验及多样本方差进行数据分析。结果：暴露组与对照组血ALP及血脂TC、TG检测指标具有显著差异（P〈0．01），血Ca^2＋、P^3＋、Mg^2＋无显著差异（P〉0．05）。氟骨症患者骨畸形程度的三度分度中Ⅰ度与Ⅱ、Ⅲ度血中ALP比较具有统计学意义（P〈0．05），而Ⅱ、Ⅲ度与Ⅲ度之间无统计学意义（P〉0．05）。结论：长期摄取过量的氟对人体血液生化中血ALP及血脂代谢TC、TG有明显的影响，血中ALP差异间接反映了氟蓄积的程度。氟骨症患者骨畸形程度与体内氟的蓄积无正相关。
Objective： The inquire the relation about the degree of skeletal deformation and fluroride- accumulation. Methods：Selected seventy flurosis pmiems freely as exposed group in Toketo aera in Inner Mongolia. and divided them into three degrees according to ThP clinical, degrees ofendemie OsteofluroSis Then selected seventy healthy pecIple as ontrol group who liVe in the rural area of Hohhot. The two group had been controled in 25-55 years old without any other diseases. They had been determined the index of blood.Ca^2＋、P^3＋、Mg^2＋, ALP and lipid such as TC, TG, Analysis these index with Independent t. test and Multiple comparisons. Results： The index ofblood - ALP, TC, TG has＇ statistic significant （ P 〈 0.01 ）, and the index of Ca^2＋、P^3＋、Mg^2＋ has none（P 〉 0.05）. The first degree ofdeformation ofbone has statistic significant（P 〈 0.05） comparing with the second and the third, there has not statistic significant（P 〉0.05）between the second and the third. Conclusion： Long period excessive fluriod absorbing would infuence blood - ALP index and lipid metabolism, which indicate the degree of fluoride accumulation. The degme of deformation of bone has no correlativity with fluoride, accumulation.
出处
《内蒙古医学杂志》
2007年第10期1185-1188,共4页
Inner Mongolia Medical Journal
关键词
氟骨症
骨畸形
Skeletal fluorosis
Deformity of bone
