摘要
目的探讨尾加压素Ⅱ(UⅡ)是否参与了慢性肺源性心脏病(简称肺心病)的发病机制。方法选择慢性肺心病患者25例和健康人20例(对照组),用放射免疫法测定血浆UⅡ的水平,超声多普勒测定肺动脉收缩压(PASP)、室间隔厚度(IVS)、右心室前壁厚度(RVAW)和右心室舒张末期内径(RVEDd),观察各组UⅡ的差异性及其与心脏超声指标的相关性。结果与对照组比较,肺心病患者缓解期血浆UⅡ水平[(2.75±1.18)pmol/L比(2.49±0.44)pmol/L]、PASP[(33.65±9.55)mmHg比(15.70±6.90)mmHg]、IVS[(10.84±2.04)mm比(9.32±1.40)mm]、RVAW[(6.56±0.95)mm比(5.21±1.69)mm]和RVEDd[(25.84±6.61)mm比(21.03±2.62)mm]均显著升高(P均<0.05)。肺心病患者在急性加重期以上指标水平较缓解期进一步显著升高[血浆UⅡ水平(3.43±1.04)pmol/L,PASP(65.94±19.14)mmHg,IVS(11.58±1.96)mm,RVAW(8.15±1.49)mm和RVEDd(38.89±9.35)mm](P均<0.05)。肺心病患者血浆UⅡ水平与PASP、RVAW分别呈正相关(r分别为0.648和0.671,P均<0.05)。结论UⅡ可能参与慢性肺心病的发生发展,血浆UⅡ水平可作为慢性肺心病严重程度的指标之一。
Objective To investigate whether urotensin Ⅱ （ UⅡ ） contributes to the pathogenesis of chronic cor pulmonale. Methods Radioimmunoassay was used to measure the plasma UⅡ in 25 patients with chronic cor pulmonale and 20 healthy controls. Ultrasonic doppler was employed to measure the pulmonary artery systolic pressure（PASP） ,thickness of interventricular septum（IVS） ,right ventricular anterior wall（ RVAW）, and right ventricular end-diastolic diameter （RVEDd）. The levels of of UⅡ in chronic car pulmonale group and control group were compared and their correlations with uhrasonographic parameters were analyzed. Results The levels of UII[ （2. 75 ± 1.18）pmol/L vs（2.49 ±0.44） pmol/L] , PASP[（33.65±9.55）mmHg vs（15.70 ±6.90） mm Hg],IVS[（10.84 ±2.04）mm vs（9.32 ± 1.40） mm], RVAW [ （ 6. 56 ± 0. 95 ） mm vs （ 5.21 ± 1.69） mm ] and RVEDd [ （25.84 ± 6. 61 ） mm vs （21.03 ± 2.62）mm ] in patients with stable chronic cor pulmonale were all higher significantly than those in the control group（ all P 〈0. 05 ）. Meanwhile,the uhrasonographic parameters got worse and UⅡ elevated during acute exacerbation of chronic car pulmonale [ UⅡ （ 3.43 ± 1.04 ） pmol/L, PASP （ 65.94 ± 19. 14） mm Hg, IVS（ 11.58 ± 1.96） ram, RVAW （ 8.15 ± 1.49 ） mm and RVEDd （ 38.89 ± 9. 35 ） mm, all P 〈 0. 05 ]. The plasma level of UⅡ was positively correlated with PASP and RVAW（ r = 0. 648 and 0. 671 respectivelly, both P 〈 0.05 ） in patients; with chronic cor pulmonale. Conclusions UⅡ may participate in the pathogenesis of chronic cor pulmonale. Measuring the levels of UⅡ may be a promoising meathod to evaluate the severity and follow the progress of chronic cot plumonale.
出处
《中国呼吸与危重监护杂志》
CAS
2007年第6期416-418,共3页
Chinese Journal of Respiratory and Critical Care Medicine
基金
黑龙江省教育厅研究生创新科研项目(编号:YJSCX2007-0090HLJ)
