摘要
目的:研究胃和结直肠肿瘤血管浸润(BVI)和淋巴管浸润(LVI)的检测方法及其临床意义。方法:应用免疫组化法检测95例胃和结直肠肿瘤组织中CD34和D2-40的表达,根据HE染色和免疫组化染色结果判断BVI和LVI,并分析其临床意义。结果:淋巴管浸润与血管浸润显著相关,P<0.001。免疫组化法发现的脉管浸润显著高于HE法发现的脉管浸润,P<0.001。肿瘤浸润深度与BVI(1.5%vs33.3%,P<0.001)和LVI(7.7%vs40.0%,P<0.001)显著相关。淋巴结转移状态与BVI(6.9%vs26.1%,P=0.022)和LVI(6.9%vs52.2%,P<0.001)显著相关。结论:免疫组化法比常规HE法有更高的特异性和敏感性;BVI和LVI可能是胃癌和结直肠癌重要的预测预后因子。
OBJECTIVE： To explore the method of detecting blood vessel invasion （BVI） and lymphatic vessel invasion （LVI） and the significance of BVI and LVI. METHODS： Expression of CD34 and D2-40 of 95 patients with gastrointestinal cancer were detected by immunohistochemistry （IHC）. BVI and LVI were detected by IHC and HE staining. RESULTS： BVI was correlated with LVI significantly, P〈0.001. IHC staining detected more vessel invasion than HE staining did, P〈0. 001. The depth of invasion of tumor was correlated significantly with BVI （ 1.5 % vs 33.3%, P〈0.001） and LVI （7.7% vs 40.0%, P〈0.001）. The statues of lymph nodes was correlated significantly with BVI （6.9% vs 26.1%, P=0.022）and LVI （6.9% vs 52.2%, P〈 0. 001）. CONCLUSIONS： The sensitivity and specificity of IHC staining was higher than those of HE staining in detecting vessel invasion. BVI and LVI seem to be prognostic factors to gastrointestinal cancers.
出处
《中华肿瘤防治杂志》
CAS
2007年第23期1795-1797,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤
结肠直肠肿瘤
肿瘤浸润
stomach neoplasms
colorectal neoplasms
neoplasm invasiveness
