摘要
目的:观察升清降浊丸对免疫性肝损伤模型小鼠细胞因子的作用机理。方法:将90只昆明小鼠随机分为6组,正常对照组,BCG+LPS模型组,香菇多糖片阳性药+BCG+LPS对照组,中药小剂量+BCG+LPS组,中药中剂量+BCG+LPS组,中药大剂量+BCG+LPS组,各组分别给予相应药物。观察升清降浊丸对免疫性肝损伤模型小鼠细胞因子TNF-α、IL-4、IL-6、IFN-γ的影响。结果:实验中升清降浊丸能明显抑制肝损伤小鼠血清丙氨酸氨基转移酶(ALT)和门冬氨酸氨基转移酶(AST)活性;抑制细胞因子肿瘤坏死因子,白介素6(TNF-α,IL-6)的水平;降低脾细胞产生Thl型细胞因子干扰素-γ(IFN-γ)的能力;降低Th2型细胞因子白介素4(IL-4)的含量。结论:升清降浊丸对细胞免疫和体液免疫均有一定的调节作用。
Objective, To probe the mechnanism of Shengqingjiangzhuo Pill on cell factor TNF-α, IL-4, IL-6, IFN-γ in the immunity Hepatic injury mice . Method： 90 mice were divided into control group, model group, positive group, high dose group , middle dose group and high dose group randomly. The content of ALT , AST, TNF-α, IL-4, IL-6 and IFN-γwere determined. Results： The content of ALT ,AST TNF-α, IL-6 and IL-4 were decreased; the ptoducing of IFN-γ in Thl type cell of spleen cell was inhibited. Conclusion： Shengqingjiangzhuo Pill has effects on cell immunity and humoral immunity.
出处
《世界中西医结合杂志》
2007年第4期210-212,共3页
World Journal of Integrated Traditional and Western Medicine
基金
河南省科技厅基金资助项目
