摘要
基于羧基化多壁碳纳米管修饰玻碳电极为工作电极,建立了无汞和高灵敏测定依诺沙星的电化学方法.在0.1 mol/L磷酸盐缓冲溶液（pH为5.91）中,在0.5 V富集5 min,然后以100 mV/s的扫描速度从0.5 V扫描至1.4 V,1次微分峰电流与依诺沙星在0.02-0.20 mg/L呈线性关系,检出限为0.01 mg/L.通过与药典方法比较,证实了方法的可靠性.该方法操作简单,灵敏度高,避免使用汞,可以用于依诺沙星胶囊含量的常规测定.
A mercury-free and high sensitive electrochemical method for the determination of enoxacin was established by using a glassy carbon electrode modified by multi-wall carbonnanotubes functionalized with carboxylic group. Differential voltammograms of enoxacin was obtained in 0.1 mol/L phosphate buffer solution of pH 5.91 at 100 mV/s after 5.0 min accumulating at 0.5 V. The oxidation currents were linear for enoxacin in the range of 0.02 - 0.20 mg/L with and the detect limit is 0.01 mg/L. The reliability of this mercury-free method was validated by comparing with the pharmacopoeia method. The proposed method was simple and sensitive, and can be applied for routine determination of enoxacin in capsule without contamination.
出处
《河北大学学报（自然科学版）》
CAS
北大核心
2007年第3期257-261,278,共6页
Journal of Hebei University(Natural Science Edition)
基金
教育部博士点学科基金项目(20050075003)
关键词
羧基化多壁碳纳米管
电化学
依诺沙星
functionalized multi-wall carbonnanotubes
electrochemistry
enoxacin
