葡萄糖-6-磷酸异构酶与类风湿关节炎研究进展被引量：10

导出

摘要类风湿关节炎（rheumatoidarthritis．HA）是危害人们健康的一种常见疾病，其患病率在结缔组织病中居首位。RA患者未经及时诊治可出现严重的关节畸形，并可累及全身多个系统，应早期诊断、早期治疗。RA的诊治一直是各国学者关注的问题．目前RA的诊断主要依靠临床症状，血清学诊断指标只有类风湿因子（RF），但RF特异性较差，不仅在RA患者中出现，在其他结缔组织病及健康老年人中都可以检测到，这也限制了它的诊断作用。近年来，抗环瓜氨酸肽（cycliccit-rullinatedpeptide，CCP）抗体等与RA早期诊断相关自身抗体谱的临床研究及应用，使RA检测的敏感性和特异性有所提高.

作者赵冠飞李永哲

机构地区首都医科大学附属北京朝阳医院检验科中国医学科学院中国协和医科大学北京协和医院检验科

出处《中华风湿病学杂志》 CAS CSCD 2007年第12期750-754,共5页 Chinese Journal of Rheumatology

基金国家自然科学基金资助项目（30471617）

关键词类风湿关节炎异构酶葡萄糖 RA患者结缔组织病健康老年人自身抗体谱磷酸

分类号 R686 [医药卫生—骨科学]

引文网络
相关文献

参考文献28

1Van Gaalen FA, Linn-Rsker SP, van Venrooij WJ, et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheun, 2004, 50: 709-715.
2Gumey ME, Heinrich SP, Lee MR, et al. Molecular cloning and expressing of neuroleukin, a neurotrophic factor for spinal and sensory neurons. Science, 1986, 234: 566-574.
3Yu FL, Liao MH, Lee JW, et al. Induction of hepatoma cell migration by phosphoglucose isomerase/autocrine motility factor through the upregulation of matrix metalloproteinase-3.Biochem Biophys Res Commun, 2004, 314: 76-82.
4Muraki Y, Matsumoto I, Chino Y, et al. Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of auto-antibody production. Biochem Biophys Res Commun, 2004, 323: 518-522.
5Fang S, Ferrone M, Yang C, et al. The tumor autocrine motility factor receptor, gp78, is a ubiquitial protein ligase implicated in degradation from the endoplasmatic reticulum. Proc Natl Acad Sci USA, 2001, 98: 14422-14427.
6Schaller M, Burton DR, Ditzel HJ. Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. Nat Immunol, 2001, 2: 746-753.
7Schubert D, Schmidt M, Zaiss D, et al. Autoantibodies to GPI and creatine kinase in RA. Nat Immunol, 2002, 3:412-413.
8Schaller M, Stohl W, Tan SM, et al. Raised Levels of anti-glucose-6-phosphate isomerase lgG in serum and synovial fluid from patients with inflammatory arthritis. Ann Rheum Dis, 2005, 64: 743 -749.
9Cha HS, Kim TJ, Lee MH, et al. Autoantibidies to glucose-6- phosphate isomerase are elevated in the synovial fluid of rheumatoid arthritis patients. Scand J Rheumatol, 2004, 33: 179-184.
10Van Gaalen FA, Toes RE, Ditzel HI, et al. Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis. Arthritis Rheum, 2004, 50: 395-399.