摘要
目的探讨血白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)及超敏C反应蛋白(hsCRP)在慢性阻塞性肺疾病(COPD)吸烟者中的作用及意义。方法将80例COPD患者分为吸烟组(n=47)和非吸烟组(n=33),50例健康查体非吸烟者为对照组;检测COPD患者加重期、缓解期及健康查体者血IL-8、TNF-α及hsCRP水平。结果IL-8、TNF-α、hsCRP水平在加重期COPD患者与对照组比较显著升高(P<0.01),吸烟组明显高于非吸烟组(P<0.05)。缓解期COPD患者与对照组比较,IL-8、TNF-α水平仍升高,且吸烟组仍显著高于非吸烟组(P<0.05),hsCRP水平各组间比较无统计学差异(P>0.05)。结论IL-8、TNF-α、hsCRP均参与了COPD急性加重期炎症反应过程,可能是反映COPD患者急性加重的敏感指标;吸烟在促进IL-8、TNF-α、hsCRP的产生、加快COPD气道炎症的进展中起着一定作用。
[ Objective] To evaluate the clinical significance of serum levels of interleukin-8 （IL-8）, tumor necrosis factor-α （TNF-α） and high-sensitivity c-reactive protein （hsCRP） in the smoking patients with chronic obstructive pulmonary disease （COPD）. [Methods] 80 patients with COPD were divided into two groups： smokers group （n = 47 ） and nonsmokers group （ n = 33）. 50 healthy nonsmokers were as the control group. The levels of IL-8, TNF-α, hsCRP were tested in COPD patients including acute exacerbation and stable period and control. [ Results ] The levels of IL-8, TNF-α and hsCRP were higher in COPD patients than that in control group （ P 〈 0.05 ）, and were higher in smokers than that in nonsmokers in acute exacerbation period （P 〈 0.05）. In stable period,the levels of IL-8, TNF-α, hsCRP decreased, but the levels of IL-8 and TNF-α were higher in COPD patients than that in the control group （ P 〈 0.05）, and they were also higher in smokers than that in nonsmokers （P 〈 0.05）. The difference of hsCRP between COPD patients and controls was not significant （P 〉 0.05）. [ Conclusions ] IL-8, TNF-α and hsCRP are involved in airway inflammation of acute exacerbation period of COPD which may be as the sensitive indexes of acute exacerbation. Smoking may play an important role in promoting the production of IL-8, TNF-α, hsCRP and speed up the progression of airway inflammation.
出处
《山东医药》
CAS
北大核心
2007年第32期42-44,共3页
Shandong Medical Journal
关键词
肺疾病
慢性阻塞性
吸烟
白细胞介素8
肿瘤坏死因子-α
超敏c反应蛋白
pulmonary disease, chronic obstructive
smoking
interleukin-8
tumor necrosis factor-α
high-sensitivity c-reactive protein
