摘要
【目的】通过血浆凝血酶原前体蛋白（PIVKA-Ⅱ）的测定,探讨第三代头孢菌素对儿童维生素K营养状况的影响。通过维生素K1预防性治疗,改善抗生素引起的维生素K缺乏状态。【方法】选择2005年10～12月间38例第三代头孢类抗生素治疗住院患儿,分为A组24例（抗生素治疗组）及B组14例（抗生素治疗＋维生素K1干预）。ELISA法测定血浆中PIVKA-Ⅱ。PIVKA-Ⅱ≥2μg/L为阳性（正常参考值〈2μg/L）。【结果】A组治疗前8例PIVKA-Ⅱ≥2μg/L,阳性率为33.33%,抗生素治疗后20例PIVKA-Ⅱ阳性,阳性率为83.33%（χ^2=12.343,P=0.001）。B组治疗前PIVKA-Ⅱ〉2μg/L者8例,阳性率为57.14%,使用维生素K1后全部转阴。【结论】第三代头孢菌素的应用引起小儿维生素K缺乏。抗生素治疗期间给予维生素K110 mg预防性治疗可改善维生素K缺乏状态。
[Objective] To investigate the influence of the third generation cephalosporin on vitamin K nutrition status in children by determining the concentration of proteins induced by vitamin K absence or antagonism （PIVKA-Ⅱ） in plasma; Preventive treatment with vitamin K1 to the children treated with antibiotics to reverse the status of vitamin K deficiency. [Methods] 38 children treated with the third generation cephalosporin between October and December in 2005. Classified as A group （24, antibiotic treated） and B group（14, antibiotic＋ vitamin K1 treated）. The concentration of PIVKA-Ⅱ in plasma were determined and quantified by enzyme immunoassay. PIVKA-Ⅱ≥2 μg/L was positive （Normal 42 μg/L）. [Results] 8 out of 24 PIVKA-Ⅱ were positive of A group ‘Before＇, The ratio of positive was 33.33 %, 20 out of 24 were positive of A group ‘After＇ antibiotic treated, The ratio of positive was 83.33% （χ^2= 12.34,P=0. 001）. 8 cases PIVKA-Ⅱ〉2 μg/L of B group ‘Before＇, The ratio was 57.14%, all of 14 reversed negative in PIVKA-Ⅱ after giving 10mg vitamin K1. [Conclusions] The third generation cephalosporin has influence on vitamin K nutrition status. Preventive treatment with vitamin K1 10mg to the children who are treated with antibiotics can reverse the status of vitamin K deficiency.
出处
《中国儿童保健杂志》
CAS
2007年第6期594-595,共2页
Chinese Journal of Child Health Care
基金
唐山市2004年科研立项课题(04134621c)
