摘要
目的研究男性肾衰血透患者重度贫血与血液中睾酮水平的相关性,并尝试以睾酮类药物对部分患者进行治疗,对其疗效进行评价。方法对80例男性肾衰血透患者血样中的睾酮水平进行ELISA检测。随后40例采用促红细胞生成素(rHuEPO)进行常规治疗,另40例患者则使用睾酮类药物联用进行治疗,并对各治疗组的结果进行评价。结果80例男性肾衰血透患者均有重度贫血症状,相应的表现为睾酮水平明显降低,与正常对照组有显著差异(P<0.01)。rHuEPO治疗组有效率达到90%(36例),睾酮水平有相应的上升,40例中8例(20%)出现血压升高。40例患者采取低剂量rHuEPO与睾酮类药物联用进行治疗,其红细胞、血红蛋白、红细胞压积等指标均可达到或接近单纯rHuEPO治疗组的效果。另6例患者单用长效睾酮加常规铁剂并联用进行治疗,短期内各项指标低于前2组,但亦显示有改善。结论男性肾衰血透患者,血液中睾酮水平明显下降,当贫血症状改善时,睾酮水平也有相应的上升。因此,对于男性肾衰血透患者采取联用睾酮类药物进行治疗,一定时间以后同样可以取得与rHuEPO治疗相似的临床效果。
Objective： To determine the correlation between testosterone levels and anemia in uremic male patients and search for the appropriate treatment for each patient. Methods ： Levels of testosterone in the sera from 80 uremic male patients were detected with the ELISA kit. Forty of the patients were treated with recombinant human erythropoietin （rHuEPO） as routine clinical practice. For the patients with hypertension during therapy, we decreased the dose of rHuEPO and added testosterone drug and jin shui bao drug. The other 40 patients received testosterone add EPO and their results were compared with rHuEPO treatment group. Results ： Serum testosterone levels in uremic male patients with anemia were significantly lower than those in normal controls. It was shown that rHuEPO therapy led to an effectual correction of anemia in 36 patients （90% of 40 patients）, but 8 patients indicated hypertension （20% of 40 patients）. Among the patients with hypertension, 6 persons received with testosterone treatment and jin shui bao drug. Combination of 50% of rHuEPO and testosterone and jin shui bao drug can resulted in the same evaluation as the normal rHuEPO therapy in erythrecyte （RBC） , hemoglobin （HB）, and hematocrit （Hct）. Conclusion： Testosterone levels in uremic male patients demonstrate a trend toward a great decrease in comparison with normal people. During rHuEPO therapy, testosterone levels increased with correction of anemia correlatively. So it is suggested that combination of rHuEPO and testosterone can both increase the hematological values significantly for the uremic male patients.
出处
《泰山医学院学报》
CAS
2007年第1期44-46,共3页
Journal of Taishan Medical College
