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DNA疫苗药代动力学研究进展

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摘要 DNA 疫苗在临床应用前需进行体内药代动力学试验,由于 DNA 疫苗是一类特殊的生物制品,故其药代动力学特性不同于通常的药物。随着分子生物学技术的迅速发展,研究 DNA 疫苗药代动力学的方法也在不断改进。本文就 DNA 疫苗药代动力学特点及其研究方法的新进展作一综述。
作者 刘畅 樊明文
出处 《国际生物制品学杂志》 CAS 2007年第6期255-258,共4页 International Journal of Biologicals
基金 国家自然科学基金(30271416)
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  • 1Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research. Guidance for industry considerations for plasmid DNA vaccines for infectious disease indications. US, 2005.
  • 2Dupuis M, Denis-Mize K, Woo C, et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol, 2000,165 (5) : 2850-2858.
  • 3Nishikawa M,Takakura Y, Hashida M. Theoretical considerations involving the pharmacokinetics of plasmid DNA. Adv Drug Deliv Rev,2005,57(5):675-688.
  • 4Tuomela M,Malm M,Wallen M,et al. Biodistribution and general safety of a naked DNA plasmid, GTU-Multi HIV, in a rat, using a quantitative PCR method. Vaccine, 2005, 23 (7) : 890-896.
  • 5Babiuk S, Baea-Estrada ME, Foldvari M, et al. Needle-free topical electroporation improves gene expression from plasmids administered in porcine skin. Mol Ther,2003,8(6) :992-998.
  • 6Koshkina NV. Agoulnik IY, Melton SL, et al. Biodistribution and pharmacokinetics of aerosol and intravenously adminis-tered DNA-polyethyleneimine complexes: optimization of pulmonary delivery and retention. Mol Ther,2003,8(2) :249-254.
  • 7Dalton SR,Wiegert RL,Casey CA. Receptor-mediated endocytosis by the asialoglycoprotein receptor: effect of ethanol ad-ministration on endosomal distribution of receptor and ligand. Liver Int,2003,23(6) :484-491.
  • 8Ward CM, Peehar M, Oupieky D, et al. Modifieation of pLL/ DNA eomplexes With a muhivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged Plasma eireulation in vivo. J Gene Med,2002,4(5):536-547.
  • 9Kang MJ,Kim CK, Kim MY, et al. Skin permeation,biodistribution, and expression of topically applied plasmid DNA, J Gene Med,2004,6(11) :1238-1246.
  • 10Dauty E, Remy JS, Blessing T, et al. Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture. J Am Chem Soc, 2001, 123(38) : 9227-9234.

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