摘要
对国内17年间甘露醇药物不良反应的临床报道进行文献计量学分析,结果表明:620例药物不良反应病例主要为肾功能损害(40.97%)、急性肾功能衰竭(24.03%)、血尿(12.26%)、代谢紊乱(6.29%)、全身严重反应(4.68%)、肠梗阻(3.71%)、神经系统反应(2.26%)、皮疹或荨麻疹(1.29%)、过敏性哮喘(1.13%)等.A型反应576例,B型反应44例,均为中、重度反应.病例年龄在8月～85岁之间,主要为51～70岁.男性病例约为女性的2倍.原发病主要为脑出血(39.52%)、脑梗塞(15.81%).
The reports on the ADRs caused by Mannitol in China over a period of 17 years was bib- liometrically analyzed. Our results showed that the reported 620 cases of ADRs included renal impairment (40.97%), acute renal failure(24. 03%), hematuria (12.26%), metabolic disorder (6.20 %), severe general reaction(4.68%), intestinal obstruction (3.71%), reaction of nerve system(2.26%), skin rash or urticaria (1.29%) and allergic asthma(1.13%) etc. There were 576 cases of type A reaction and 44 cases of type B reaction, which were moderate or severe ADRs. The age of the patients ranged from 8 months to 85 years and most of them were aged from 51-70 years old. Male cases were 2 times female cases. The primary diseases mainly included cerebral hemorrhage(39.52%) , cerebral infarction (15.81%).
出处
《药物流行病学杂志》
CAS
1997年第3期153-155,共3页
Chinese Journal of Pharmacoepidemiology
关键词
甘露醇
不良反应
文献计量学
Mannitol
ADRs
Renal function
Bibliometrics
