摘要
目的探讨利培酮对于氯丙咪嗪治疗强迫症的增效作用。方法将70例强迫症随机分为2组,氯丙咪嗪同时合并利培酮和单独使用氯丙咪嗪治疗,治疗8周。采用强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定疗效。结果合并利培酮组有31例完成试验,氯丙咪嗪组有32例完成试验。治疗8周后,两组Y-BOCS平均总分有明显下降,合并利培酮组优于氯丙咪嗪组,两组无显著性差异(P<0.05);HAMA、HAMD的评分均显著下降,两组无显著性差异(P>0.05)。结论合并利培酮对于氯丙咪嗪治疗强迫症有增效作用。
Objective： To investigate the superior effectiveness of risperidone combining with clomipramine in the tretment of obsessive- compulsive disorder （OCD） . Methods： 31 patients with OCD were treated by risperidone combining with clomipramine and 32 patients were treated by clomipramine only for 8 weeks , The efficacy was measured with Yale - Brown obsessive compulsive scale （ Y - BOCS） , Hamilton anxiety scale （HAMA） and Hamilton depression scale （HAMD）. Results ： Mter 8 weeks, there were significant differences between two groups in overall response showed by the reduction rate of Y - BOCS total scores ; whereas no snignificant differences in HAMA and HAMD total scores between them. Conclusion： It is suggested that risperidone combining clomipramine have a superior effectivenees in the treatment of OCD.
出处
《上海精神医学》
2007年第4期221-223,共3页
Shanghai Archives of Psychiatry
关键词
利培酮
氯丙咪嗪
强迫症
Risperidone Clomipramine Obsessive - compulsive disorder
