摘要
目的探讨婴儿麻疹急性期的T细胞亚群、自然杀伤细胞(NK)和CD19^+T细胞改变及其发病机制,为指导临床治疗提供理论依据。方法采用直接免疫荧光法,应用流式细胞仪检测25例麻疹患儿外周血T细胞亚群、NK和CD19^+T细胞,并与对照组和儿童麻疹组比较。结果(1)婴儿麻疹急性期淋巴细胞绝对数明显减少,但亚群中CD3^+、CD4^+T细胞未见减少;(2)婴儿麻疹感染急性期CD19^+T细胞均明显低于对照组和儿童麻疹感染急性期[(14.67±8.70)%vs(24.18±6.72)%vs (24.02±8.83)%](P<0.01)。结论婴儿期麻疹感染时,CD3^+、CD4^+T细胞抑制不明显,CD19^+T细胞受到严重的抑制。
Objective To investigate the changes of T cell subsets, natural killer cells （NK） and CD19^＋ T cells as well as its pathogenesis in order to provide a theoretical basis for clinical treatment and reduce infant mortality rate of measles. Methods Peripheral blood T cell subsets, NK and CD19^＋ T cells were measured by direct immunofluorescence techniques associated with flow cytometry in 25 measles infants and these values were compared with the counterparts of control group and elderly children with acute measles. Results （1） Absolute count of peripheral blood T lymphocyte in infants with acute measles was reduced obviously, but no decrease in CD3^ ＋ , CD4^ ＋ T cell subgroups was found; （2） CD19^ ＋ T cells of infants with acute measles were significantly lower than that in the control group and the elderly children infected with acute measles [（14.67±8.70）% vs.（24.18±6.72）% vs.（24.02±8.83）%]（P〈0.01）.Conclusion Measles infection in infancy led to obvious inhibition of CD19^＋ T cells while CD3^＋, CD4^＋ T cells showed little inhibition.
出处
《中国小儿急救医学》
CAS
2007年第6期491-493,共3页
Chinese Pediatric Emergency Medicine
