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SNP分型方法及在法医学等领域的应用 被引量：3

SNP Typing Methodology and Its Application in Forensic Science
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摘要 随着单倍型图的产生,SNP越来越受到关注。不仅仅在Y染色体和线粒体,常染色体和X染色体上的SNPs的应用潜能也将被发现。SNPs具有比较低的突变率和适合于降解DNA分析的特点,在法医学领域也受到关注。本文综合介绍了SNPs和X-SNPs的一般特性、分型方法及其在法医学的应用。 Due to the haplotype map. SNPs show potential advantage not only on X-chromosome and autosomal but also on Y chromosome and mtDNA. In the forensic field,the interest of SNPs is continuously increasing because of the low mutation rates and suitability for analysis of degraded DNA. This report mainly describe the SNPs and X-chromosome SNPs characteristics, genotyping methods and its potential application in forensic medicine.
作者 郭宏 畅晶晶 李莉
机构地区 苏州大学基础医学院 司法部司法鉴定科学技术研究所 司法部司法鉴定科学技术研究所 复旦大学上海医学院法医学系
出处 《中国司法鉴定》 2007年第6期22-25,共4页 Chinese Journal of Forensic Sciences
关键词 单核苷酸多态性 X-染色体 SNP-分型 single nueleotide polymorphism （SNP） X-chromosome： SNP genotyping
分类号 DF795.2 [医药卫生—法医学]
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参考文献10

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同被引文献27

  • 1李凤刚,李桢.浅谈道路交通事故的法医学检验与鉴定[J].科学技术与工程,2004,4(9):795-797. 被引量：3
  • 2王会品,刘超,孙宏钰.MiniSTR技术的研究进展[J].法医学杂志,2006,22(2):159-160. 被引量：10
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  • 4Georgina Meakin,Allan Jamieson.DNA transfer:Review and implications for casework[J].Forensic Sci.Int.Genet,2013(7):434-443.
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  • 6P.Gill,L.Gusm-o,H.Haned,et al.DNA commission of the International Society of Forensic Genetics:Recommendations on the evaluation of STR typing results that may include drop-out and/or drop-in using probabilistic methods[J].Forensic Sci.Int.Genet,2012(6):679-688.
  • 7Robert Pomeroya,George Duncanb,Bulbin Sunar-Reeder,et al.A low-cost,high-throughput,automated single nucleotide polymorphism assay for forensic human DNA applications[J].Analytical Biochemistry,2009,(395):61-67.
  • 8Yi-Liang Wei,Cui-Jiao Qin,Hui Dong,et al.A validation study of a multiplex INDEL assay for forensic use in four Chinese populations[J].Forensic Sci.Int.Genet,2013:http://dx.doi.org/10.1016/j.fsigen.2013.09.002.
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  • 10刘海东,任甫,邢瑞仙,裴林国.烧骨个体识别的研究进展[J].法医学杂志,2009,25(1):61-62. 被引量：5

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中国司法鉴定
2007年 第6期

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