摘要
目的:探讨了精神分裂症患者治疗前后血清NO/NOS和TNF-α水平的变化及意义。方法:应用放免法和化学法对41例精神分裂症患者进行了治疗前后血清NO/NOS和TNF-α水平的变化,并与35名正常健康人作比较。结果:精神分裂症患者在治疗前血清NOS、TNF-α水平非常显著地高于正常人组(P<0.01),而NO水平则显著地低于正常人组(P<0.01),经治疗6周后与正常人组比较仍有显著性差异(P<0.05)。结论:检测精神分裂症患者血清NO/NOS和TNF-α水平的变化与患者的病情和愈后密切相关,具有重要的临床价值。
Objective To explore the significance of changes of serum NO/NOS and TNF - α levels in patients with shcizophrenia. Methods Serum TNF -α （with RIA） and NO/NOS （with bio -chemistry） levels were determined in 41 patients with schizophrenia both before and after treatment as well as in 35 controls. Results Before treatment the serum NOS, TNF - α levels in the patients were significantly higher than those in controls （ P 〈 0.01 ）. After six weeks treatment, the levels in patients, though dropped markedly, remained significantly higher （P 〈 0.05 ）. Conclusion Serum NO/NOS and TNF - α levels were closely related to the diseases process of schizophrenia and were of prognostic values.
出处
《放射免疫学杂志》
CAS
2007年第6期506-508,共3页
Journal of Radioimmanology
关键词
精神分裂症
一氧化氮
一氧化氮合成酶
肿瘤坏死因子-Α
schizophrenia, nitric oxide （NO）, nitric oxide synthase （NOS）, tumor necrosis factor- α（ TNF -α）
