摘要
目的:探讨了慢性肾炎患者治疗前后血清leptin、TNF-α水平变化及意义。方法:应用放射免疫分析对31例慢性肾炎患者进行了治疗前后血清leptin、TNF-α检测,并与35例正常健康人作比较。结果:慢性肾炎患者在治疗前血清leptin、TNF-α水平非常显著地高于正常人组(P<0.01),经治疗6个月与正常人组比较仍有显著差异(P<0.05)。结论:检测慢性肾炎患者血清leptin和TNF-α水平的变化对临床观察和预后有重要的临床价值。
Objective To explore the clinical significance of changes of serum leptin and TNF - α levels in patients with chronic nephritis. Methods Serum leptin and TNF -α （with RIA） levels were determined in 31 patients with chronic nephritis both before and after treatment as well as in 35 controls. Results Before treatment the serum leptin and TNF - α levels were signifieanfly higher than those in controls （P 〈 0.01 ）. After treatment for six months, the levels in patients though dropped markedly, remained signifieanfly higher （ P 〈 0.05 ）. Conclusion Changes of serum leptin and TNF - α levels after treatments might be of prognoStie importance in patients with chronic nephritis.
出处
《放射免疫学杂志》
CAS
2007年第6期513-514,共2页
Journal of Radioimmanology
关键词
慢性肾炎
瘦素
肿瘤坏死因子-Α
chronic nephritis, leptin, tumor necrosis factor - α（ TNF - α）
