摘要
目的:探讨肝硬化患者血清中胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、脂联素和透明质酸(HA)的关系及临床意义。方法:应用放射免疫分析对178例肝硬化患者进行血清IGF-Ⅰ、脂联素和HA含量测定,同时设60名健康体检者为正常对照组。结果:肝硬化患者血清IGF-Ⅰ、脂联素水平较正常组显著降低(P<0.01,P<0.05),而HA水平明显升高,且二者与HA水平呈负相关(r=-0.737、-0.692,P<0.01)。结论:检测血清IGF-Ⅰ、脂联素和HA水平对判断病情的轻重和预后观察均具有重要的临床价值。
Objective To investigate the significance of changes of serum IGF - Ⅰ , adiponectin and HA contents in patients with hepatic cirrhosis. Methods Serum IGF - Ⅰ , adiponectin and HA levels were measured with RIA in 178 patients with cirrhosis and 60 controls. Results The serum level of IGF - Ⅰ and adiponectin were significantly lower in the patients than those in controls （P 〈 0. 01, P 〈 0. 05）, while the serum HA level was significantly higher. Conclusion Detection of serum IGF - Ⅰ, adiponectin and HA levels is valuble for the diagnosis, assessment of the disease process and outcome prediction in patients with cirrhosis.
出处
《放射免疫学杂志》
CAS
2007年第6期540-542,共3页
Journal of Radioimmanology
