摘要
目的探讨血清胃蛋白酶原(pepsinogen,PG)和幽门螺旋杆菌感染与萎缩性胃炎(AMB)的关系,以及血清PG检测在慢性萎缩性胃炎诊断中的价值。方法选取108例慢性胃炎患者,行胃镜检查做病理诊断,其中非萎缩性胃炎患者(non-AMB)30例,慢性轻度萎缩性胃炎患者28例,中度萎缩性胃炎患者24例,重度萎缩性胃炎患者26例,并以正常胃黏膜(NM)32例作对照。用ELISA法定量检测PGⅠ、PGⅡ浓度和幽门螺旋杆菌Hp-IgG抗体。结果在HP-IgG抗体阳性和HP-IgG抗体阴性患者中,随着胃体黏膜由NM→non-AMB→AMB转变,血清平均PGⅠ、PGⅠ/PGⅡ都逐渐降低,且与病变程度呈负相关;同一组中血清平均PGⅠ、PGⅡ在HP-IgG抗体阳性组与阴性组间差异无显著性。结论通过检测血清PGⅠ、PGⅡ浓度可评价胃黏膜萎缩的程度和对胃癌进行早期诊断。
Objective To investigate the relationship between serum pepsinogen levels as well as anti-HP IgG with atrophic gastritis. Methods 108 cases were selected in the study,gastric diseases were diagnosed by endoscopy and histopathologic examination, including 30 cases of chronic nonatrophic gastritis,28 cases of chronic mild atrophic gastritis and 24 cases of chronic moderate atrophic gastritis, and 26 cases of chronic severe atrophic gastritis and 32 normal subjects were measured, serum pepsinogen Ⅰ, pepsinogen Ⅱ levels and anti-HP IgG were detected by quantitative ELISA kits. Results NM→non-AMB→AM, with positive and negative anti-HP IgG, serum PG Ⅰ and PG Ⅰ/PG Ⅱ levels of in chronic atrophic gastric group was significantly lower than that of other groups, serum PGⅠ I and PG Ⅰ/PG Ⅱ was negatively correlated with the degree of malignity of gastric mucosa. There were no obvious differences of serum PG Ⅰand PGⅠ/PG Ⅱ levels between positive anti-HP IgG and negative anti-HP IgG in the same groups. Conclusion Serum PG I and PG Ⅰ/PG Ⅱ measurement may estimate the extent of atrophic gastric mucosa in patients and to raise
出处
《河南科技大学学报（医学版）》
2007年第4期260-261,共2页
Journal of Henan University of Science & Technology:Medical Science
关键词
血清胃蛋白酶原
幽门螺旋杆菌
萎缩性胃炎
Key words： serum pepsinogen
helicobacter pylori
atrophic gastritis
