摘要
探讨了虫草多糖对家犬夹闭肾动脉造成的急性肾衰的治疗作用。将实验动物家犬分为假手术组、阴性模型组、阳性组、虫草多糖高、中、低三个剂量组,观察治疗后犬的肾功能、血液生化指标、尿常规、肾脏病理的变化。发现虫草多糖组肾功能受损程度明显轻于阴性模型组(P<0.01),肾脏病理损伤明显减轻。实验证明虫草多糖能够治疗肾缺血诱发的急性肾功能衰竭,其机理可能与改善肾功能、增加肾血流量、纠正代谢紊乱、促进肾小管的修复与再生等作用有关。
The therapeutic effects of Cordyceps polysaccharide（CP） on occluding renal artery-induced acute kidney injury in dog were studied ,36 adult dogs were randomly divided into six groups, sham operation group, model group, Cordyceps polysaccharide group CP 160 mg/kg, CP 80 mg/kg and CP 40 mg/kg, and Dexamethasone group. The models of acute renal failure were established by occluding renal artery. After management, renal function, biochemical indicator, urine routine and renal pathologic changes were observed. Compared with the model group, the degree of injury of renal function in Cordyceps polysaccharide group dogs were palliated significantly （ P 〈 0.01 ）, renal pathologic changes were palliated significantly. Cordyceps polysaccharide has a remarkable effect on renal ischemia-induced acute kidney injury. The mechanisms could be relevant to improving renal function, increasing renal blood flow, correcting metabolic disorder, and promoting regeneration of renal tubule.
出处
《生物加工过程》
CAS
CSCD
2007年第4期70-75,共6页
Chinese Journal of Bioprocess Engineering
基金
国家自然科学基金资助项目(30500458)
关键词
虫草多糖
肾缺血
急性肾衰
Cordyceps polysaccharide
renal ischemia
acute renal failure
