摘要
目的:观察苏红透骨摩药治疗风湿痹痛的临床疗效,并研究其透皮吸收功能。方法:应用中药外用摩药剂——苏红透骨摩药治疗风湿痹痛诸症(骨刺、跌打损伤、肩周炎、关节周围软组织急性损伤或慢性劳损)患者300例,并以苏红透骨散治疗的120例患者作对照,观察2组的临床疗效。通过小鼠透皮实验考察苏红透骨摩药中有效成分麝香酮、冰片、薄荷脑对本制剂透皮行为的影响。结果:治疗组总有效率为93.24%,对照组总有效率为80.00%,2组比较有显著性差异(P<0.05)。麝香酮、冰片、薄荷脑对苏红透骨摩药有一定的促渗效果。结论:苏红透骨摩药是治疗风湿痹痛诸症较理想的外用制剂。以麝香酮、冰片、薄荷脑为复方时苏红透骨摩药的透皮吸收速率较好。
OBJECTIVE：To observe the clinical efficacy and transdermal absorption of Suhong bone-penetrating massage drug for rheumatic arthralgia. METHODS： Suhong bone- penetrating massage drug（Chinese medicine） was applied in 300 cases with rheumatic arthralgia characterized by various symptoms such as bone spur, injury, scapulohumeral periarthritis, acute injury or chronic strain of articular surrounding soft tissue; Suhongtougu powder was used as control to treat another 120 cases with the same disease. The curative efficacies in two groups were compared. The effects of the effective components such as Muskone, Borneo Camphor, Menthol in Suhong bone-penetrating massage drug on the transdermal absorption of this preparation was investigated by transdermal test on mice. RESULTS： The total effective rate in the treatment group was 93.24% as compared with 80.00% in the control group, showing significant difference between two groups（P〈0.05）.Muskone, Borneo Camphor and Menthol could promote the transdermal absorption of Suhong bone - penetrating massage drug. CONCLUSION： Suhong bone- penetrating massage drug has been proved to be an ideal external preparation for different symptoms of rheumatic arthralgia. With Muskone, Borneo Camphor and Menthol as compound recipe, optimal transdermal absorption is available for Suhong bone- penetrating massage drug.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第36期2852-2854,共3页
China Pharmacy
关键词
苏红透骨摩药
风湿痹病
临床疗效
透皮吸收功能
苏红透骨散
Suhong bone penetrating massage drug
Rheumatic arthralgia
Clinical efficacy
Transdermal absorption
Suhongtougu powder
