摘要
以丙二酸二乙酯和硝酸胍为原料,在醇钠的碱性体系中发生亲核加成-消去反应(环化)首先合成了2-氨基-4,6-二羟基嘧啶;然后经氯化和烷氧基化反应合成了2-氨基-4,6-二甲氧基嘧啶。采用单因素法探索了反应时间、pH值和催化剂等因素对产物收率的影响,优化了反应条件,达到节省能源、降低成本和简化操作的效果,有利于大规模的工业化生产。
The intermediate 2 - amino - 4,6 -7 dihydroxypyrimidine was first synthesized with diethyl malonate and guanidine nitrate as raw materials by reaction of nucleophilic addition - elimination reaction （cyclization） in sodium ethylate. Then, 2- amino-4,6- dimethoxypyrimidine was synthesized by chlorination reaction and alkoxylation reaction. In order to obtain maximal yield of the products, the effect of reaction time, pH value and catalyst was studied by single factor experiment. The experimental conditions were optimized, and the optimized method is featured of energy saving, lower cost, easier operation. It is conducive to large - scale industrialization production.
出处
《淮阴工学院学报》
CAS
2007年第5期70-72,共3页
Journal of Huaiyin Institute of Technology
关键词
2-氨基嘧啶
合成
加成-消去反应
2 - aminopyrimidine
synthesis
addition - elimination reaction
