摘要
目的：观察硒对二乙基亚硝胺（ＤＥＮ）诱发大鼠肝癌的影响。方法：在诱癌过程中，大鼠分别投予含０．２、１．０、３．０×１０－６硒（Ｓｅ）的饲料，检测血、肝组织ＬＰＯ、ＧＳＨ－Ｐｘ活性，观察诱癌率及癌结节面积。结果：补Ｓｅ后对诱癌率无显著影响，但补充３．０×１０－６Ｓｅ可使癌结节面积显著减少；补Ｓｅ可显著地减轻诱癌早期血和肝组织中ＬＰＯ的形成及诱癌过程中血和肝组织中ＧＳＨ－ＰＸ活性的降低。结论：Ｓｅ可能具有通过提高ＧＳＨ－Ｐｘ活力、抑制脂质过氧化作用而抑制肝癌生长的作用。
Objective: To observe the inhibitory effects of Se on diethylnitrosamine (DEN)induced hepatocarcinogenesis. Methods: During carcinogenesis, Wistar rats were fed with 3 different dietary levels of Se (0.2, 1.0 and 3.0×10-6 respectively). Then the activities of LPO and GSHPx in the blood and liver were determined and the tumor incidence and area of tumor nodules observed. Results: Supplementation of Se significantly inhibited the increase of LPO in both blood and liver at the early stage of carcinogenesis and restored the values of GSHPx in the red blood cells and liver. Conclusion: Se might inhibit the growth of liver cancer through improving the activity of GSHPx and depressing the lipid peroxidation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第3期254-256,共3页
Journal of Third Military Medical University
关键词
硒
二乙基亚硝胺
肝肿瘤
肿瘤生长
致癌物
Se
diethylnitrosamine
liver cancer
gluthione peroxidase
lipid peroxide
rat
