摘要
目的:观察全身伽玛刀后程治疗食管癌的临床疗效和并发症。方法:2002年7月至2006年3月常规放疗联合全身伽玛刀后程治疗食管癌患者127例。常规放疗2.0 Gy.d-1,每周5 d,共40 Gy;4周后停照,行伽玛刀后程治疗,4.0 Gy.d^-1,每周5 d,共10次,分析疗效和并发症。结果:治疗后,满意(n=44)和基本好转(n=64)者85.03%(108/127),1年生存率为77.95%(99/127),吞咽困难评分从治疗前3.5±0.17降至0.75±0.28(P〈0.01),Ⅰ-Ⅱ级和Ⅲ-Ⅳ级放射性食管炎的发生率分别为25.19%(32/127)和7.87%(10/127),食管支气管瘘和食管狭窄各1例,血液系统毒性轻微。结论:常规放射治疗联合伽玛刀放疗符合食管癌放射治疗的原则,可降低放射治疗的副作用,提高局部控制率。
Objective: To observe the curative effect and complication of esophageal carcinoma treated with traditional radiotherapy(RT) and poststage Gamma knife system conformal radiotherapy( GKS -CRT). Methods: Analyzed 127 cases of esophageal carcinoma treated with Gamma knife and RT from 2002 to 2006. RT consisted of 2. 0 Gy per fraction, to a total dose of 40 Gy, followed by 4. 0 Gy per fraction with GKS - CRT to 80 Gy. Results: The efficiency reach 85.03% ( 108/127 ), survival at 1 year was 77.95% ( 99/127 ), reduction in mean dysphagia score from 3.5±0. 17 to 0. 75 ±0. 28(P 〈0. 01) ,esophagitis grade Ⅰ - Ⅱ and grade Ⅰ - Ⅳ was 25. 19% (32/127) and 7.87% (10/127) respectively,one occurred eso - respiratory fistulae and one occurred esophageal stenosis. Conclusions:GKS - CRT combined RT is feasible to the patients with esophageal carcinoma,with better curative effect and less complications.
出处
《现代临床医学》
2007年第6期424-426,共3页
Journal of Modern Clinical Medicine
基金
四川省科学技术厅2004年重点科技自筹项目04JY029-122
关键词
食管癌
伽玛刀治疗
放射疗法
esophageal neoplasm
Gamma knife system conformal radiotherapy
radiotherapy