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抗氧化剂α-硫辛酸对2型糖尿病大鼠动脉组织NF-κB表达的影响 被引量：8

Effect of antioxidant α-lipoic acid on NF-κB expression in the aorta of type 2 diabetic Goto-Kakisaki rats
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摘要 目的:观察α-硫辛酸对2型糖尿病大鼠氧化应激状态和动脉组织核转录因子κB(NF-κB)表达的影响。方法:采用免疫组化方法观察高脂喂养12周正常Wistar大鼠、2型糖尿病Goto-Kakisaki(GK)鼠和硫辛酸治疗GK鼠(隔天1次腹腔注射α-硫辛酸35mg/kgBW)的主动脉组织NF-κB和iNOS的表达,并测定血清MDA、SOD、GSH水平。结果:12周GK鼠血清MDA水平明显高于,SOD和GSH水平明显低于对照组,主动脉内皮NF-κB和iNOS表达明显增强,而硫辛酸治疗后血清MDA水平明显低于糖尿病组,SOD和GSH水平明显高于糖尿病组,同时主动脉组织NF-κB和iNOS表达与正常对照组相似。结论:2型糖尿病存在着明显的氧化应激状态,α-硫辛酸通过清除氧自由基而抑制动脉组织NF-κB的表达。
作者 徐雷 冯波 王华 王军臣 符雪莲
机构地区 同济大学附属东方医院内分泌科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2007年第12期2474-2475,2493,共3页 Chinese Journal of Pathophysiology
关键词 糖尿病 NF-ΚB 硫辛酸 氧化性应激 Diabetes mellitus NF- κappa B Thioctic acid Oxidative stress
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

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二级参考文献19

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中国病理生理杂志
2007年 第12期

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