摘要
目的通过检测C-met基因产物在胃黏膜良、恶性病变中的表达,探讨其对提高胃癌早期诊断的意义。方法采用免疫组织化学S-P法检测正常胃黏膜、肠上皮化生、癌旁不典型增生、胃癌中的表达。结果C-met基因产物在肠上皮化生、癌旁不典型增生、胃癌间表达差异无统计学意义(P>0.05),但是表达三者均显著高于正常胃黏膜(P<0.01)。结论C-met基因表达与胃黏膜增殖恶化有关,是胃癌发生的早期现象。
[ Objective] To deteet the manifestation of C-met gene products in the gastric mucosa benign and malignant lesions with an aim of exploring its significance in the early diagnosis of gastric cancer. [ Methods] Immunohistochemical SP method was applied to detect the manifestation of normal gastric mucosa, intestinal metaplasia, carcinoma nontypical hyperplasia and gastric cancer. [Results] No significant difference was found in the manifestation of C-met gene products in intestinal metaplasia, carcinoma nontypical hyperplasia and gastric cancer （ P 〈0.05） , but the manifestations of them were all higher than that of the normal gastric mucosa （P〈0.01）. [Conclusion] C-met gene manitestation is proved to be related with the malignant gastric mucosa hyperplasia and the early phenomenon of gastric cancer.
出处
《职业与健康》
CAS
2008年第1期93-94,共2页
Occupation and Health
