摘要
目的探讨区域性缓释化疗在胃肠道恶性肿瘤的疗效。方法98例胃肠道恶性肿瘤患者采用直视下植入用缓释氟尿嘧啶或直接将缓释氟尿嘧啶撒布在腹腔、盆腔的瘤床周围进行区域性化疗。结果患者腹、盆腔给药后,未见出血、吻合口漏、肠穿孔、肠梗阻、腹腔化脓性感染;所有患者手术切口Ⅰ期愈合;未见明显全身不良反应。随访6月至3年,死亡18例,均为晚期手术不能切除者,失访16例,局部复发2例,肝脏等其他器官转移2例。结论缓释氟尿嘧啶进行区域性化疗具有缓释和靶点的双重特性,体现了显著的药效学效果,患者耐受性良好。
Objective To evaluate the therapeutic effect of regional sustained-release chemotherapy in gastrointestinal malignancies. Methods For regional chemotherapy, 98 patients with gastrointestinal malignancies were implanted with Fluorou- racil implants to the tumor bed region in abdominal cavity, pelvic cavity at the time of operation. Results There were no bleed- ing, stomal leak, intestinal perforation, intestinal obstruction and celiopyosis after operation and Fluorouracil implant. The opera- tive incision of all patients were healed at stage I ~ After 6 months to 3 years of follow up, 18 patients died, in whom all belonged to advanced stage malignancies and failed to be ablated. 16 patients were lost of follow up. Local recurrence occurred in 2 patients and distant metastasis to other organs such as liver in 2 patients. Conclusion There are two characteristics in regional chemo- therapy using Fluorouracil implants ： sustained-release and target. The significant therapeutic effect and good tolerance of patients are also its superiority.
出处
《实用医院临床杂志》
2008年第1期31-32,共2页
Practical Journal of Clinical Medicine
关键词
胃肠
恶性肿瘤
缓释化疗
区域性
氟尿嘧啶
Gastrointestine
Malignancy
Sustained-release chemotherapy
Regionality
Fluorouracil
