摘要
目的探讨牛磺酸对伴有高同型半胱氨酸(Hhcy)血症的脑梗死患者的治疗作用。方法100例Hhcy脑梗死患者随机分为牛磺酸治疗组和叶酸+维生素治疗组,给予相应的药物治疗8周。治疗前后分别测定血同型半胱氨酸(Hcy)、叶酸、维生素B12水平;采用美国国立卫生院神经功能缺损评分量表(NIHSS)及日常生活活动能力指数(BI)进行评分。结果治疗后两组血浆Hcy水平较治疗前显著下降(均P<0.01),但两组间差异无统计学意义;治疗后两组NIHSS及BI评分较治疗前显著改善(均P<0.01),但两组间差异无统计学意义。结论牛磺酸治疗对Hhcy脑梗死患者的疗效与叶酸、维生素B12相同。
Objective To investigate the therapeutic action of Taurine in patients with cerebral infarction （CI） induced by hyperhomocysteinemia （Hhcy）. Methods The 100 CI patients induced by Hhcy were randomly divided to two therapy groups. One group was administered Taurine, the other group was administered Folacin combined with Vitamine B12 for 8 weeks. Before and after treating, the serum levels of homocysteic acid （ Hcy）, Folacin and Vitamine B12 were detected, NIHSS and B! were evaluated. Results The serum levels of Hcy were significantly decreased after administering in both two groups （ all P 〈 0.01 ）, and there was no significant difference between them. There were significant differences in two groups about NIHSS and BI before and after administering（ all P 〈 0. 01 ） ,and no significant difference between them. Conclusion The therapeutic action in patients with CI induced Hhcy by Taurine or Folacin combined with Vitamine B12 is same.
出处
《临床神经病学杂志》
CAS
北大核心
2007年第6期461-462,共2页
Journal of Clinical Neurology
基金
黑龙江省卫生厅科研资助项目(2006-481)
