摘要
目的:研究硒化卡拉胶口服液对环磷酰胺诱导免疫抑制小鼠的非特异性免疫功能、体液免疫功能、细胞免疫功能的影响。方法:小鼠腹腔注射80mg/kg环磷酰胺诱导免疫抑制小鼠模型;硒化卡拉胶口服液连续灌胃30d,每天1次。测定小鼠单核巨噬细胞吞噬功能、血清半数溶血素值、迟发型变态反应(DTH)、T淋巴细胞及B淋巴细胞增殖能力、白介素-1(IL-1)及白介素-2(IL-2)活性。结果:硒化卡拉胶口服液(30、10μg/kg)均可增强T淋巴细胞增殖能力及DTH;硒化卡拉胶口服液30、10、5μg/kg均可升高单核巨噬细胞吞噬功能、血清半数溶血素值,增强B淋巴细胞增殖能力及IL-1、IL-2活性。结论:硒化卡拉胶口服液对免疫抑制小鼠的免疫功能具有改善作用。
AIM： To investigate the effects of selenoearrageenan syrupus on nonspecifie immunity, humoral immunity, cell immmunity of immune suppressed mice with cyclophosphamide. MIETHODS： Intraperitoneal injecting cyclophosphamide（80 mg/kg, i. d. ） in mice for 3 days to make immunity hypofunction mice model and given selenocarrageenan syrupus by gastric gavage for 30 days. We tested the mononuclear phagocyte englobemem function, serum haemolysin, delayed hypersensitivity （DTH）, interlukine-1,2（IL-1, 2）activity and T, B lymphocyte proliferating function. RESULTS： High and medium dose（30, 10 μg/kg）of selenocarrageenan syrupus increased mononuclear phagocyte englobement function, T lymphocyte proliferating function and delayed hypersensi- tivit significantly. All 3 doses increased serum haemolysin, IL-1,2 activity and B lymphocyte proliferating function significantly. CONCLUSIION： The results suggest that selenoearrageenan syrupus could promote the immunological function of immune suppressed mice.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2007年第11期1269-1273,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
