摘要
目的:研究表皮生长因子受体(EGFR)在人涎腺腺样囊性癌组织和细胞系中的表达及其临床病理学意义。方法:采用免疫组化S-P法对86例不同亚型的人涎腺腺样囊性癌组织病理切片、20例正常腮腺组织切片及ACC-2细胞爬片进行EGFR的检测;激光共聚焦显微镜对ACC-2细胞中EGFR的表达情况进行检测。结果:在涎腺腺样囊性癌组织中EGFR呈过度表达,其阳性率要明显高于正常腮腺组织(P<0.05);EGFR的表达在腺样囊性癌的恶性程度相关(P<0.05);ACC-2细胞中也检测到了EGFR的过度表达。结论:EGFR表达与腺样囊性癌恶性度及预后密切相关。
Objective： To study the expression and significance of epidermal growth factor receptor （EGFR）in salivary gland adenoid cystic carcinoma（ACC）, Methods： S-P immunohistochemical method was used to examine the EGFR in 86 cases of ACC,20 cases of normal salivary gland and ACC-2 corpuscular piece. ACC-2 corpuscular piece also examined by laser confocal microscopy, Results： The expression of EGFR in each hypotype of adenoid cystic carcinoma was prominent higher than the normal parotid glands tissue （P〈0.05） in immunohistochemical staining and laser confocal microscopy, Overexpression of EGFR also been found in ACC-2 corpuscular piece samples, Conclusion： The expression of EGFR in ACC has close relationship with the malignant degree and prognosis of patients,
出处
《口腔颌面外科杂志》
CAS
2007年第4期320-323,共4页
Journal of Oral and Maxillofacial Surgery
关键词
腺样囊性癌
表皮生长因子
adenoid cystic carcinoma
epidermal growth factor
