摘要
目的比较全身应用乙酰唑胺和局部应用0.5%阿可乐宁控制老年性超声乳化白内障吸除术(超乳术)后控制眼内压的效果。方法选择36例受试者36眼,随机选择12眼局部应用0.5%阿可乐宁行术后治疗,12例(12眼)口服乙酰唑胺,其余12眼不给予降压药药物治疗(对照组)。统计资料主要采用方差分析。结果阿可乐宁组手术后24 h的眼内压明显低于对照组(P<0.01)。结论该项前瞻性研究表明,阿可乐宁可有效的预防超乳术后眼内压的升高。采用阿可乐宁的病人其眼内压低于乙酰唑胺组和对照组病人。考虑到局部应用危险性较小,因此认为超乳术后最好采用0.5%的阿可乐宁,而不采用口服乙酰唑胺。
Objective To compare the effects of systemically administered acetazolamide and topical apraclonidine 0. 5% in the control of intraocular pressure （ IOP） following phacoemulsification of senile cataracts. Methods Thirty-sixeyes in 36 patients were selected. Twelve eyes randomly assigned to postoperative treatment with topical apraclonidine 0. 5% , 12 received oral acetazolamide and the remaining 12 received no hypotensive treatment （ control group）. Statistical analyses were performed mainly by means of analysis of variance. Results IOPs measured 24 h after surgery were significantly lower （ P 〈 0. 01 ） in the apraclonidine group compared to the control group. Conclusions Our prospective study shows that apraclonidine is effective in the prevention of lOP increases following phacoemulsification of senile cataracts, lOPs in patients with apraclonidine were lower than those in the acetazolamide and control group. Considering the lower risk of toxicity associated with topical administration, topical apraclonidine 0. 5% seems to be preferable to oral acetazolamide in this postoperative setting.
出处
《滨州医学院学报》
2007年第6期435-437,共3页
Journal of Binzhou Medical University
