摘要
目的探讨高血压患者B型脑钠肽(BNP)与左室肥厚(LVH)和舒张功能异常(LVDD)的相关性。方法入选84例高血压患者,根据左室重量指数(LVMI)分为左室肥厚组和正常组;根据舒张功能不全(LVDD)诊断标准分为舒张功能不全组和正常组,测定其脑钠肽浓度。结果脑钠肽与左室后壁厚度(LVP-WT)和LVMI成正相关(r=0.74P<0.01;r=0.61P<0.01),与E/A值和舒张早期血流播散速率(FPV)成负相关(r=0.74P<0.01;r=0.61P<0.01)。结论在心功能正常的高血压患者中,BNP是预测LVH和LVDD有价值的生化指标。
Objective To explore the correlation between plasma BNP and left ventricular hypertrophy （LVH） and left ventricular diastolic dysfunction （LVDD） in patients with hypertension. Methods Eighty-four patients were divided into the LVH group and the control group based on the LVMI, and they were also divided into the LVDD group and control group based on the LVDD. Results The BNP levels were positively correlated with LVMI and LVPWT （ r = 0.74 P 〈 0.01; r=0.61 P〈0.01） and were negatively correlated with E/A and FPV （r= -0.66 P〈0.01; r = -0.65, P 〈 0.01 ）. Conclusions BNP is a valuable biochemical quota for predicting LVH and LVDD in patients with normal left ventricular function.
出处
《山东大学学报（医学版）》
CAS
北大核心
2007年第12期1282-1284,1288,共4页
Journal of Shandong University:Health Sciences
关键词
高血压
脑钠肽
左室肥厚
舒张功能异常
Hypertsnsion
Brain natriuretic peptide
Left ventricular hypertrophy
Left ventricular diastolic dysfunction
