期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GDNF对精原干细胞增殖及其分化的调控机制 被引量：2

Roles of GDNF in the Proliferation and Differentiation of Spermatogonial Stem Cells
下载PDF
导出
摘要 阐述了胶质细胞源性神经营养因子(GDNF)及其受体与精原干细胞增殖和分化的关系。GDNF能够促进未分化的精原细胞增长,并且可以调节精原干细胞自我更新与分化的微环境,参与其分化的第一步,是精原干细胞存活的重要营养因子。 The roles of glial cell line-derived neurotrophic factor （GDNF） and its receptors during the processes of proliferation and differentiation in spermatogonial stem cells were reviewed in this article. It has been proved that GDNF gets involved in the activation of undifferentiated spermatogonia growth, the regulation of the micro-environment of spermatogonial stem cell self-renewal/differentiation and the participation in the first step of differentiation. According to these researches, GDNF is an important nutritional factor in the survival of spermatogonial stem cells.
作者 刘姗姗 李树峰 李丹丹 杨丹 严云勤
机构地区 东北农业大学生命科学学院组织胚胎学教研室
出处 《细胞生物学杂志》 CSCD 2007年第6期831-834,共4页 Chinese Journal of Cell Biology
关键词 胶质细胞源性神经营养因子 精原干细胞 自我更新 分化 glial cell line-derived neurotrophic factor spermatogonial stem cells self-renewal differentiation
分类号 Q2 [生物学—细胞生物学]
  • 相关文献

二级参考文献7

  • 1[1]de Rooij DG. Proliferation and differentiation of spermatogonial stem cells[J]. Reproduction, 2001, 121 (3) :347-354.
  • 2[2]Jiang FX. Behaviour of spermatogonia following recovery from busulfan treatment in the rat[J]. Anat Embryol(Berl) , 1998,198 ( 1 ):53-61.
  • 3[3]Jing S, Wen D, Yu Y, et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF[J]. Cell, 1996, 85(7) :1113-1124.
  • 4[4]Tadokoro Y, Yomogida K, Ohta H, et al. Homestatic regulation of germinal stem cell proliferation by GDNF/FSH pathway [ J ].Mech Dev, 2002, 113( 1 ) :29-39.
  • 5[5]Meng X, Lindahl M, Hyvonen M, et al. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF [ J ]. Science, 2000, 287(5457): 1489-1493.
  • 6[6]Lin LF, Doherty DH, Lile JD, et al. GDNF: a glial cell-derived neurotrophic factor for midbrain dopaminergic neurons [ J ]. Science, 1993, 260(5111) :1130-1132.
  • 7[7]Soler RM, Dolcet X, Encinas M, et al. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factor signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons [ J ]. J Neurosci, 1999,19 ( 21 ): 9160-9169.

共引文献98

同被引文献49

  • 1李彦锋,郭应禄,李晓红,靳凤烁,孙中义.人精原干细胞的体外培养及其功能鉴定[J].中华男科学杂志,2005,11(12):886-890. 被引量：5
  • 2Kanatsu-Shinohara M, Ogonuki N, lwano T, et al. Genetic and epigenetic properties of mouse male germline stem ceils during long-term culture. Development, 2005, 132 (18) : 4155-4163.
  • 3Kanatsu-Shinohara M, Inoue K, Lee J, et al. Generation of pluripotent stem cells from neonatal mouse testis. Cell, 2004, 119 (7) : 1001-1012.
  • 4Ryu BY, Kubota H, Avarbock MR, et al. Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat. PNAS, 2005, 102(40) : 14302-14307.
  • 5Oatley JM, Avarbock MR, Telaranta AI, et al. Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc Natl Acad Sci USA, 2006, 103(25) : 9524-9529.
  • 6Tadokoro Y, Yomogida K,Ohta H, et al. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech Dev, 2002, 113 (1) : 29-39.
  • 7Kubota H, Mary R, Avarbock, et al. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A, 2004, 101(47) : 16489-16494.
  • 8Hofmann MC, Braydich-Stolle L, Dym M. Isolation of male germ-line stem ceils: Influence of GDNF. Dev Biol, 2005, 279 (1) : 114-124.
  • 9Piirsoo M, Kaljas A, Tamm K, et al. Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro. Neurosci Lett, 2010, 469( 1 ) : 135-140.
  • 10Zuping H, Jiji J, Hofmann MC, et al, Gfral silencing in mouse spennatogonial stem ceils results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod, 2007, 77 (4) : 723-733.

引证文献2

二级引证文献9

细胞生物学杂志
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部