期刊文献+

乳腺癌组织中趋化因子受体CCR7的表达及其意义 被引量:5

Expression and its value of chemokine receptor CCR7 expression in breast cancer
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摘要 目的:检测乳腺癌中趋化因子受体CCR7的表达及其临床意义。方法:收集65例根治性切除的乳腺癌标本,用免疫组织化学法检测CCR7的表达,分析CCR7的表达与乳腺癌患者临床病理特征之间的相关性。结果:65例标本中,42例存在CCR7的高表达(64.6%),CCR7的表达与乳腺癌患者的淋巴结转移、TNM分期和肿瘤组织中淋巴细胞的浸润程度密切相关,但与淋巴结转移的数目无关。结论:趋化因子受体CCR7与乳腺癌淋巴结转移密切相关,其在乳腺癌的临床诊治中有参考价值。 Objective:To detect the expression and its value of CCR7 in breast cancer. Methods:CCR7 expression was investigated by means of immunohistochemistry in 65 patients with breast cancer who underwent radical mastectomy. The correlation of CCR7 expression and other clinical features was analyzed. Results:CCR7 receptor was expressed in 42 cases (64.6%). The CCR7 expression was significantly associated with lymph node metastasis, stage and lymphocyte infiltration. But the number of metastatic lymph node was not associated with the expression of CCR7. Conclusion:CCR7 receptor plays an important role in the lymph node metastasis in breast cancer, which could be used in the clinical practice of breast cancer.
出处 《临床肿瘤学杂志》 CAS 2007年第12期906-908,共3页 Chinese Clinical Oncology
基金 云南省教育厅资助项目(No.06Y143C)
关键词 趋化因子受体CCR7 乳腺癌 免疫组织化学法 淋巴结转移 CCR7 Breast cancer Immunohistochemistry Lymph node metastasis
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参考文献5

  • 1Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis[ J]. Int J Cancer, 2003, 105:186-189.
  • 2马飞,宁力,张颖妹,徐兵河.趋化因子受体CCR7促进乳腺癌细胞的趋化与侵袭[J].第四军医大学学报,2004,25(20):1883-1886. 被引量:21
  • 3Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [ J ]. Nature,2002,410 : 50 -56.
  • 4Cabioglu N, Yaziei MS, Arun B, et al. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer[J]. Clin Cancer Res, 2005, 11:5686 -5693.
  • 5Andre F, Cabioglu N, Assi H, et al. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer [ J ]. Ann Oncol, 2006, 17:945-951.

二级参考文献14

  • 1Müller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [J]. Nature, 2001; 410:50-56.
  • 2Ding Y, Shimada Y, Maeda M, et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma [J]. Clin Cancer Res, 2003; 9:3402-3412.
  • 3Mashino K, Sadanaga N, Yamaguchi H, et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma [J]. Cancer Res, 2002; 62:2937-2941.
  • 4Takanami. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis [J]. Int J Cancer, 2003; 105(2): 186-189.
  • 5Baggiolini M. Chemokines and leukocyte traffic [J]. Nature, 1998; 392: 565-568.
  • 6Murphy PM. Chemokines and the molecular basis of cancer metastasis [J]. N Engl J Med, 2001; 345:833-835.
  • 7Taichman Rs, Cooper C, Keller ET, et al. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone [J]. Cancer Res, 2002; 62:1832-1837.
  • 8Bertolini F, Agnola CD, Mancuso P, et al. CXCR4 neutralization, a novel therapeutic approach for Non-Hodgkins Lymphoma[J]. Cancer Res, 2002; 62:3106-3112.
  • 9Geminder H, Sagi-Assif O, Goldberg L, et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma [J]. J Immunol, 2001; 167(8):4747-4757.
  • 10Dellacasagrande J, Schreurs OJ, Hofgaard PO, et al. Liver metastasis of cancer facilitated by chemokine receptor CCR6 [J]. Scand J Immunol, 2003; 57(6):534-544.

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