摘要
目的观察盐酸丁咯地尔对急性脑梗死的治疗效果。方法60例急性脑梗死患者被随机分为两组各30例,治疗组发病72 h内应用盐酸丁咯地尔150 mg加入0.9%氯化钠溶液250 ml静滴,1次/d,15 d为1个疗程,对照组胞二磷胆碱0.5加入0.9%氯化钠溶液100 ml静脉滴注.每日2次,血栓通0.75 g加入0.9%氯化钠溶液250 ml静脉滴注,每日1次,连用15 d。治疗组、对照组治疗前后分别进行神经功能缺损程度评分并做对比分析。结果治疗前后神经缺损评分,经统计学处理,两组治疗前差异无统计学意义P>O.05),治疗组前后差异非常显著(P<0.01),治疗组治疗后,基质金属蛋白酶-9改善显著好于对照组(P<0.05)。结论盐酸丁咯地尔能显著改善急性脑梗死患者神经功能且无明显不良反应。
Objective To investigate the therapeutic effect of buflomedil hydrochoride for on jection inprogressive ischemic stroke. Methods 60 patients with cerebral infarction were divided into buflomedil hydrochoride for injection treatment group and control treatment. Then the nepal function deficits of patients were evaluated before and after 15 days. Serum MMP-9 levels in vein blood samples of ischemic stroke were detected. Results The incidence rate of progressive ischemic stroke in treatment group of buflomedil hydrochoride for injection was lower than that of control treatment group（P 〈 0.05 ）. Serum MMP-9 levels were significantly improved in treatment group. Conclusion The treatment of buflomedil hydrochoride for injection could decrease the incidence of progressive ischemic stroke. There might be a close relation between MMP-9 levels and ischemic stroke.
出处
《中国基层医药》
CAS
2007年第11期1827-1828,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑梗死
丁咯地尔
明胶酶B
Brain infarction
Buflomedil
Gelatinase B
