摘要
目的探讨狼疮性肾炎(LN)患者血清中白细胞介素(IL)-6和可溶性IL-2受体(sIL-2R)的水平变化及临床意义。方法利用酶联免疫吸附试验(ELISA)检测42例LN患者和40例正常健康人血清IL-6和sIL-2R的水平。结果活动期LN组患者IL-6和sIL-2R水平显著高于静止期LN组患者及正常对照组(P<0.01),静止期LN组患者IL-6和sIL-2R水平显著高于正常对照组,差异有显著性(P<0.01)。结论LN患者血清IL-6和sIL-2R显著升高,可能与LN的发生发展有关,并可作为病情及疗效判断的观察指标。
Objective To investigate the change of IL-6 and slL-2R serum level in patients with lupus nephritis（LN） and its clinical meaning. Methods The serum level of II,-6 and slL-2R were detected with ELISA in 42 cases of LN patients and 40 healthy controls. Results The serum level of IL-6 and slL-2R in lupus nephritis patients in active stage were significantly higher than patients in quiescent stage and healthy controls（ P 〈 0. 01 ）, and the serum level of sIL-6 and IL-2R in patients in quiescent stage were significantly higher than healthy controls. Conclusion The serum level of IL-6 and slL-2R were significantly higher in patients with lupus nephritis, which may be associated with the development of lupus nephritis. It could be an indicator of state of the illness and therapeutic effect for lupus nephritis patients.
出处
《国际内科学杂志》
CAS
2007年第12期688-689,727,共3页
International Journal of Internal Medicine
