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抗肿瘤新药替吉奥钾研究进展 被引量:54

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摘要 1发展概况 替吉奥钾即S-1,它由日本大鹏药品工业公司开发,1999年在日本首次获准上市,商品名TS-1。替吉奥钾实是抗肿瘤药替加氟(tegafur)的一种改进型制剂,其除此活性成份外还含有两种用来调节该药生物效应的物质吉美司特(gimestat,亦称gimeracil,化学名5-氯-2.4-二羟基吡啶,
作者 马培奇
出处 《中国医药导刊》 2007年第6期499-502,共4页 Chinese Journal of Medicinal Guide
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  • 1Malet-Martino M, Martino R. Clinical studies of three oral prodrugs of 5 - fluorouracil (capecitabine, UFT, S-1): A review. Oncologist, 2002; 7 (4): 288 -323
  • 2Hoff PM. the tegafur - based dihydropyrimidine dehydrogenase inhibitory fluoropyrimidines, UFT/leucovorin and S- 1: A review of their clinical development and therapeutic potential, Invest New Drugs, 2000; 18 (4) : 331 - 342
  • 3白坂哲彦 佃守 犬山征夫他.新规经口抗癌剂TS-1(S-1)[J].癌と化学疗法(日文),2001,28(6):855-864.
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  • 5Aventis - Sanofi Group. S - 1 oral antlcancer agent improves patients' survival in adjuvant gastric cancer trial versus surgery alone (Press releases)o http:// en. sanofi-aventis.com/press/ppc-15653.asp (January 19, 2007)
  • 6Maehara Y. S - 1 in gastric cancer: A comprehensive review. Gastric Cancer, 2003; 6 (Suppl 1) : 2- 8
  • 7Nagashima F, Ohtsu A, Yoshida S, et al. Japanese nationwide post - marketing survey of S - 1 in patients with advanced gastric cancer. Gastric Cancer, 2005; 8 (1): 6-11
  • 8Aventis - Sanofi Group. S - 1, a novel oral fluoropyrimidine, when combined with cisplatin, demonstrates significant improvement in overall survival of advanced gastric cancer patients over S - 1 alone (Press releases) . http:// en. sanofi - aventis.com/press/ppc-16728.asp (June 3, 2007)
  • 9Ohtsu A, Baba H, Sakata Y, et al. Phase Ⅱ study of S - 1, a novel oral fluoro- phyrimidine derivative, in patients with metastatic cotorectal carcinoma. Br J Cancer, 2(XX); 83 (2) : 141-145
  • 10Jeung HC, Rha SY, Cho BC. et al. A phase Ⅱ trial of S - 1 monotherapy in metastatic cotorectal cancer after failure of irinotecan - and oxaliplatin - containing regimens. Br J Cancer, 2006; 95 (12): 1637-1641

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