摘要
以胆固醇(Ch)喂饲家兔进行动脉粥样硬化(AS)造型,通过测定血浆脂质、脂质过氧化物、前列腺素水平和血小板功能以及主动脉组织生化和组织学分析,系统观察了硝苯吡啶(N)对实验性AS病变消退的影响。结果显示:N能显著降低总Ch、低密度脂蛋白Ch、载脂蛋白B(ApoB)水平,升高高密度脂蛋白Ch(HDL—Ch)、HDL_2—Ch水平;抑制脂质过氧化,降低血浆丙二醛水平;升高血浆前列环素水平,降低血栓素A_2水平,抑制血小板聚集和释放功能;减少主动脉组织Ch,ApoB和钙的沉积;减少主动脉粥样斑块面积及斑块厚度和减轻粥样病变程度。结果表明,N能促进AS病变的消退。
Model of experimental atherosclerosis (AS) was reproduced by peeding rabbits with cholesterol(Ch). Plasma lipids, lipid peroxid, prostaglandins, platelet functions and tissue biochemistry and histological analysis in aorta were examined. Effects of nifedipine on regression of experimental AS were systematically observed. The results indiceated that nifedipine showed significant effects on: lowering plasma total Ch, low dcnsity lipoprotein Ch and apolipoprotein B(ApoB); elevating plasma high density lipoprotein Ch (HDL-Ch) and HDL_2-Ch; inhibiting lipid peroxidation and reducing plasma malondialdehyde content; increasing plasma prostacyclin level and decreasing thromboxane A_2 level and inhibiting platelet aggregation and release reaction; reducing the accumulation of Ch, ApoB and calcium in aortic tissue; lessening the area and thinkness of atherosclerotic plaque as well as the degree of atherosclerotic lesion in aorta. These results suggested that nifedipine promoted the regression of AS.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1997年第4期424-428,共5页
Chinese Journal of Pathophysiology
关键词
硝苯吡啶
动脉粥样硬化
Nifedipine · Atherosclerosis· Regression · Rabbits
