摘要
目的评价抗环瓜氨酸肽（CCP）抗体和葡萄糖-6-磷酸-异构酶（GPI）抗原对类风湿关节炎（RA）的诊断价值。方法用酶联免疫吸附试验（ELISA）法分别测定RA患者112例、非RA其他风湿病患者44例以及健康志愿者119名血清中的抗CCP抗体、GPI抗原和IgM—RF，应用ROC比较抗CCP抗体和GPI抗原对RA的诊断价值，用Spearman方法分析上述指标与lgM—RF的相关性。结果在诊断RA时．抗CCP抗体和GPI抗原的ROC曲线下面积均大于IgM—RF（P均〈0．05）。抗CCP抗体、GPI抗原与IgM—RF显著相关。CCP抗体与GPI抗原的联合试验的灵敏度达到0．946。结论联合测定抗CCP抗体和GPI抗原对RA具有较高的诊断价值，具有良好的应用前景。
Objective To assess the diagnostic value of anti-cyclic citrullinated peptide antibodies （anti-CCP） and glucose-6-phosphate isomerase （GPI） for rheumatoid arlhritis （RA）. Methods The level of serum anti-CCP, GPI and IgM-RF in 112 patients with RA, 44 patients with other rheumatic diseases and 119 normal controls were determined by ELISA. The diagnostic value of these two antibodies for RA were compared by receiver operating characteristic curve （ROC）. The correlation between these antibodies and IgM-RF was assessed by Spearman. Results For the diagnosis of RA, the area under curve of anti-CCP and GPI was sig- nificantly larger than that of IgM-RF. Anti-CCP and GPI was correlated with IgM-RF. Conclusion The level of serum anti-CCP and GPI have high value in diagnosing RA.
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第1期33-35,共3页
Chinese Journal of Rheumatology
基金
上海市卫生局科研资助项目（99428）
