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残毁性掌跖角化病 被引量：1

A case of mutilating palmoplantar keratoderma
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摘要 报告1例残毁性掌跖角化病。患者女,21岁。因掌跖角化过度11年,双手指远端指间关节环形缩窄半个月,左手中指远端指间关节伸侧破溃4d就诊。右手皮损组织病理检查:表皮角化过度,颗粒层、棘层肥厚,表皮突延长,真皮浅层小血管周围散在淋巴细胞浸润。诊断:残毁性掌跖角化病。 A case of mutilating palmoplantar keratoderma is reported. A 21-year-old female presented hyperkeratosis of the palms and soles for 11 years, constriction bands in the distal interphalangeal joints of the hands for half a month, ulceration on the extensor surface of the distal interphalangeal joints of the middle finger of the left hand for 4 days. Histopathologic examination of the lesion on the right hand showed hyperkeratosis, thickening of granular layer, acanthosis, elongation of the fete pegs, perivascular infiltration of lymphocytes in the superficial dermis. The patient was diagnosed as mutilating palmoplantar keratoderma.
作者 郭玲 张谊芝 徐晨 王倩
机构地区 四川大学华西医院皮肤性病科
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2008年第1期34-35,共2页 Journal of Clinical Dermatology
关键词 角化病 掌跖 残毁性 keratoderma, palmoplantar, mutilating
分类号 R758.53 [医药卫生—皮肤病学与性病学]
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参考文献7

  • 1张义明 陈建军.残毁性掌跖角皮症1例.临床皮肤科杂志,2000,29(1):57-57.
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  • 3Maestrini E, Korge BP, Ocana-Sierra J, et al. A missense mutation in connexin 26, D66H, causes mutilating keratodenna with sensorineural deafness (Vohwinkel's syndrome) in three unrelated families[J]. Hum Mol Genet, 1999, 8(7): 1237-1243.
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二级参考文献4

共引文献9

同被引文献6

  • 1胡玉贤,贾爱华,王大虎,四荣联,李玉平.残毁性掌跖角化病1例[J].临床皮肤科杂志,2007,36(3):158-158. 被引量：1
  • 2lossa S, Chinetti V, Auletta G, et al. New evidence for the correlation of the p.G130V mutation in the GJB2 gene and syn- dromic hearing loss with palmoplantar keratodermaJJ]. Am J Med Genet A, 2009, 149A(4): 685-688.
  • 3Bakirtzis G, Choudhry R, Aasen T, et al. Targeted epidermal expression of mutant Connexin 26 (D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders[J]. Hum Mol Genet, 2003, 12(14): 1737- 1744.
  • 4de Zwart-Storm EA, Hamm H, Stoevesandt J, et al. A novel missense mutation in GJB2 disturbs gap junction protein transport and causes focal palmoplantar keratoderma with deafness[J]. J Med Genet, 2008, 45(3): 161-166.
  • 5Schmuth M, Fluhr JW, Crumrine DC, et al. Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis) [J]. J Invest Dermatol, 2004, 122(4): 909-922.
  • 6Yoneda K, Demitsu T, Nakai K, et al. Activation of vascular endothelial growth factor receptor 2 in a cellular model of lorierin keratoderma[J]. J Biol Chem, 2010, 285(21): 16184-16194.

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临床皮肤科杂志
2008年 第1期

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