摘要
目的探讨乳腺癌转移抑制基因(breast cancer metastasis suppressor 1,BRMS1)在声门上型喉鳞状细胞癌组织中的表达及其临床意义。方法免疫组化法检测60例原发性声门上型喉癌组织(肿瘤组)和其相邻的癌旁正常喉黏膜(对照组)石蜡标本组织细胞中BRMS1蛋白的表达。结果对照组均有较强的BRMS1蛋白的表达,肿瘤组阳性表达率为35.0%(21/60),且均为低表达,两者之间差异有统计学意义(P<0.05)。BRMS1蛋白在病理高分化标本中阳性表达率为43.6%(17/39),在中、低分化标本阳性表达率19.0%(4/21),两者之间差异有统计学意义(P<0.05);在临床Ⅱ期标本阳性表达率为72.7%(8/11),临床Ⅲ+Ⅳ期标本阳性表达率26.5%(13/49),两者之间差异有统计学意义(P<0.05);颈部淋巴结N0组标本阳性表达率72.7%(16/22),颈部淋巴结N+组阳性率13.7%(5/38),两者之间差异有统计学意义(P<0.05)。BRMS1蛋白阳性组患者与BRMS1蛋白阴性组患者的术后生存率无统计学差异(P>0.05)。结论BRMS1蛋白在声门上型喉癌中低表达或不表达,且其表达可能与声门上型喉癌的临床分期、病理分化以及颈部淋巴结转移有关。
Objective To investigate the expression of breast cancer metastasis suppressor 1 （BRMS1）protein in supra-glottie cancer and to evaluate its clinical significance. Methods The expression of BRMS1 protein was determined by using the immunohistochemical method in 60 cases of paraffin-embeded supraglottic cancer tissues and their surrounding laryngeal normal mucosa tissues（LNT）. Results The expression of BRMS1 protein was positive in 35.0%（21/60） cases of carcinoma and 100% （60/60） in LNT, and it was lower in supra-glottic cancer than in normal mucosa, also it was significantly different between supra-glottic cancer tissues and the LNT（ P 〈 0.05）. The expression of BRMS1 protein in supra-glottic carcinoma was related to the histological grade（ P 〈 0. 05）, that in a high cell differentiation was 43.6% （17/39） and in a moderate and a low cell differentiation was 19.0% （4/21）, and it was related to the clinical stage that in stage Ⅱ was 72.7%（8/11）and in stage Ⅲ-Ⅳ was 26.5%（13/49）, also it was related to cervical lymphatic metastasis（ P 〈 0.05）, that with cervical lymphatic metastasis was 13.7% （5/38） and without cervical lymphatic metastasis was 72.7% （16/22）. The 3 and 5-year survival was not significantly different between the positive and the negative groups. Conclusion Expression of BRMS1 protein in supra-glottie cancer is lower than that in normal mueosa. The decrease of BRMS1 protein expression may be related to the clinical stage, low differentiation and cervical lymph node metastasis of supra-glottie cancer.
出处
《山东大学耳鼻喉眼学报》
CAS
2007年第6期481-483,490,F0003,共5页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
辽宁省自然科学基金资助项目(9522019)
关键词
BRMS1蛋白
喉肿瘤
癌
声门上型
BRMS1 protein
Laryngeal neoplasms
Supraglottic cancers
