摘要
右美托咪啶是高选择性的α_2激动剂,具有镇静、镇痛、抗焦虑作用。被右美托咪啶镇静的患者血流动力学和呼吸功能稳定,可随时唤醒,与医护人员交流并配合检查和治疗。右美托咪啶在拔管期间亦可持续使用,有助于脱机困难者脱离呼吸机。可加强阿片类药物和镇静药的作用,显著减少其用量,并可预防和治疗撤药反应。大量临床试验证实其在重症监护病房镇静中具有独特优势,尤其适用于躁动、创伤、高血压、心动过速、缺血性心脏病、心脏移植等患者。
Dexmedetomidine（DXM） is a highly selective alpha- 2 agonist and works as sedative, analgesic and antianxiety agent. Patients sedated by DXM is arousable to communicate and cooperate with the medical staff. DXM could be used during extubation to facilitate ablactation. Opiod is reinforced by DXM, and the dosage needed is cut down. In addition, I）XM rebounds to the prevention and treatment of the withdrawl syndrom. Clinical trials have approved its advantage on the sedation in ICU.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第6期540-543,共4页
International Journal of Anesthesiology and Resuscitation
关键词
右美托咪啶
药理学
镇静
dexmedetomidine
pharmacology
sedation
