摘要
目的:探讨复方甘草酸苷治疗药物性肝损伤的作用。方法:将60例由应用抗结核药物所引起的药物性肝损伤患者随机分为治疗组和对照组,前者给予复方甘草酸苷,后者给予肌苷、维生素C等治疗,3周为1疗程;对两组临床疗效进行分析比较。结果:两组患者症状、体征的恢复无明显差异(P>0.05)。治疗组治愈及好转28例(93.3%),对照组治愈及好转22例(73.3%),治疗组肝功能损害恢复情况优于对照组,两组差异显著(P<0.05)。结论:在结核患者进行抗结核治疗过程中,应加强肝功能监测;复方甘草酸苷治疗抗结核药物引起的药物性肝炎疗效显著。
OBJECTIVE： To study the efficacy of compound glycyrrhizin on hepatic lesion induced by antituberculosis drugs. METHODS： A total of 60 patients with hepatic lesion induced by antituberculosis drugs were enrolled and randomly assigned to receive compound glycyrrhizin （trial group） or inosine plus vitamin C etc （control group） for 3 weeks. The clinical efficacy in two groups was compared. RESULTS： There were no significant differences between two groups in symptoms and signs after treatment （ P 〉 0.05）. 28 cases （93.3%） in trial group as compared with 22 （73.3%） in control group were cured or took a favorable turn （ P 〈 0.05）. The treatment group showed a better improvement than in control group in hepatic lesion, showing significant differences in two groups （P 〈 0.05）. CONCLUSION： Importance should be attached to the monitoring of hepatic function in the anti - tuberculosis treatment for patients with pulmonary tuberculosis. Compound glycyrrhizin has remarkable efficacy on hepatic lesion induced by antituberculosis drugs.
出处
《中国医院用药评价与分析》
2007年第6期456-457,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
复方甘草酸苷
抗结核药物性肝损害
临床疗效
Compound glycyrrhizin
Hepatic lesion induced by antituberculosis drugs
Clinical efficacy
