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等效剂量舒芬太尼与芬太尼全麻术后静脉自控镇痛的临床效果比较 被引量:4

Comparison of Sufentanil to Fentanil on patient-control intravenous analgesia after general anesthesia
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摘要 目的:比较舒芬太尼与芬太尼对全麻术后静脉自控镇痛(PCIA)的临床效果及副作用发生率。方法:选择择期全麻手术患者60例,ASAⅠ级~Ⅱ级。随机分为两组,每组30例。结束前30min使用PCIA(背景剂量2.5 ml/h,PCA 5ml/次,镇定时间8min)。Ⅰ组芬太尼4mg/ml;Ⅱ组舒芬太尼0.8mg/ml。观察术后2h、4h、8h、12h、24 h、48h镇痛(VAS)和镇静评分,记录血压、脉搏、呼吸频率的变化及恶心、呕吐等不良反应。结果:两组患者均镇痛良好,舒芬太尼组各时点的镇痛评分最低,与芬太尼组相比差异有显著性(P<0.05)。镇静效果差异无显著性(P>0.05);两组间不良反应发生率差异无显著性(P>0.05)。结论:舒芬太尼的镇痛效果是安全、有效、可行的,可在临床推广。 Objective To evaluate the value and side effects of patient-control intravenous analgesia (PCIA) with sufentanil and fentanil after general anesthesia. Methods 60 cases graded ASA Ⅰ - Ⅱ were randomly divided into two groups. Before 30 minutes at the end of operation, Ⅰ group received with 4 mg/ml fentanil; Ⅱ group received with 0.8 mg/ml sufentanil, PCIA include background 2.5 ml/h and bolus of 5 ml with lockout-time 8 minutes, and the outcomes were evaluated by recording the patients ,visualanalogscale(VAS) at 2 h ,4 h ,8 h, 12 h,24 h ,48 h after operation. The change of pressure,pulse , breathing and side effects such as nausea and vomiting were also recorded. Results Two groups showed good pain relief. In the Ⅱ group, VAS were all lower than that in the Ⅰ group ( P 〈 0.05 ). But there was no significant difference between Ⅰ and Ⅱ group in patients( P 〉0.05). There were no differences in side effects in two groups (P 〉 0.05). Conclusion Postoperative analgesia with sufentanil was proved to be a good method to manage postoperative pain after general anesthesia for patients.
出处 《实用医技杂志》 2007年第31期4260-4261,共2页 Journal of Practical Medical Techniques
关键词 舒芬太尼 芬太尼 静脉自控镇痛 Sufentanil Fentanil Patient-control intravenous analgesia
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