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帕金森病重要的发病机制：α-突触核蛋白异常聚集 被引量：9

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摘要 帕金森病（PD）是一种常见于中老年人的慢性进展的神经系统变性疾病，其病因及发病机制尚不完全清楚，目前认为是遗传因素与环境因素共同作用的结果。研究表明α-突触核蛋白异常聚集与PD的发病密切相关。目前已知某些基因变异导致PD发生，其中α-突触核蛋白基因突变（如A53T、A30P或基因染色体座位的3倍扩增）及2个与α-突触核蛋白降解机制——泛素蛋白酶体系统有关的基因（泛素C末端水解酶、Parkin）突变可引起α-突触核蛋白在细胞内异常蓄积聚合，已经被确定为家族性PD的主要原因。
作者 王少君 彭国光
机构地区 重庆医科大学附属第一医院神经内科
出处 《中华医学杂志》 CAS CSCD 北大核心 2008年第1期65-68,共4页 National Medical Journal of China
关键词 Α-突触核蛋白 发病机制 蛋白异常 帕金森病 聚集 泛素蛋白酶体系统 神经系统变性疾病 病重
分类号 R686 [医药卫生—骨科学]
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参考文献25

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同被引文献139

  • 1姚庆和,张华,高国栋.帕金森病小鼠模型行为学检测方法的比较研究[J].中国实验动物学报,2006,14(4):264-270. 被引量：19
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中华医学杂志
2008年 第1期

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