摘要
抗体芯片作为蛋白质芯片的一种,具有高通量、高特异性及平行性分析的优点,目前已被应用到许多领域,成为蛋白质组学研究过程中不可缺少的技术。但是如何构建高敏感度、微型化及检测动力学范围广的抗体芯片以满足样品检测的需要,仍然是抗体芯片发展过程中所面临的重要挑战。就如何提高其检测灵敏度作一综述。
Antibody arrays, as a specific subset of protein arrays, are now used in a wide variety of applications. Although having evolved into indispensable tools for proteomic studies, they seems to be still at the middle point on the way to the final destination to have the antibody arrays with high sensitivity, minimized size and wide dynamic detection range to meet the needs for the detection of different samples. This article reviewed the reeent development regarding how to improve the detection sensitivity of the antibody arrays.
出处
《国际生物医学工程杂志》
CAS
2007年第6期327-329,共3页
International Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30571476)
卫生部课题基金资助项目(WKJ20042006)
关键词
抗体芯片
免疫检测
灵敏度
antibody array
immunoassay
sensitivity
