摘要
观察人工虫草醇提液治疗４／６肾截除肾衰大鼠肝脏和肌肉蛋白合成速率（ＳＬ％／ｄ，ＳＭ％／ｄ）。方法虫草治疗９０天时，用大剂量３Ｈ苯丙氨酸（３Ｈｐｈｅ）注入，测定组织蛋白标记物的掺入量，以观察大鼠ＳＬ％／ｄ，ＳＭ％／ｄ。结果虫草能有效地降低Ｓｃｒ和ＢＵＮ，减慢Ｃｃｒ下降，提高Ａｌｂ和Ｈｂ，减少尿蛋白量，纠正脂质代谢紊乱。ＳＬ％／ｄ和ＳＭ％／ｄ明显高于ＣＲＦ对照组，但低于正常组。结论虫草醇提液能减少ＣＲＦ大鼠蛋白尿，纠正脂代谢紊乱，改善贫血和提高ＳＬ％／ｄ和ＳＭ％／ｄ。
Objective To investigate the effect of artificial Cosdyceps Sinensis (ACS) on the rates of protein synthesis in liver (SL%/d) and muscle (SM%d) of rats with chronic renal failure (CRF). Methods 30 rats served as normal controls (Group Ⅰ). The 90 nephrectomized rats were subdivided into 2 groups: ACS (ethanol extract 5.0g·kg 1 /d) treated group (Group Ⅱ, n=45) and chronic renal failure control (normal saline) group (Group Ⅲ, n=45). The rate of protein synthesis in liver (SL%/d) and muscle (SM%/d) was determined by 3H phenylalanine radioactive tracer:90 days after experiment. Results As compared with group Ⅲ, group Ⅱ presented:(1)significant lower levels of Scr、BUN、TG、Tch and UprV(P<0 05,0 01); (2) Higher levels of Ccr、Hb、Alb; (3) Higher rate of SL%/d and SM%/d. Conclusion ACS extract can reduce proteinuria, correct lipid metabolic disorder, improve anemia and increase the rates of SL%/d and SM%/d in rats with CRF.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1997年第4期199-201,共3页
Chinese Journal of Nephrology
关键词
人工虫草
醇提液
慢性
肾功能衰竭
蛋白合成速率
Artificial cordyceps ethanol extracts Chronic renal failure Rate of protein synthesis
