摘要
目的测定血管性痴呆(VD)与非痴呆脑血管病(NDCVD)患者及健康老年者血清叶酸、Vitamin B_(12)水平,同时评估认知功能的变化,分析并探讨其在VD的可能作用。方法选择VD40人,为痴呆组;NDCVD40人,为非痴呆组;同期选定40名健康老年人作为对照组。应用MMSE对3组对象的认知功能进行评定,测定被试着血清叶酸、Vitamin B_(12)水平。初步观察补充叶酸、Vitamin B_(12)对VD认知功能的影响。结果3组血清叶酸、Vitamin B_(12)水平(以中位数M及95%的可信区间CI表示),以VD组最低为4.20ng/ml(4.07～5.50)、343.67pg/ml(296.54～413.73)。与对照组比较有显著性(P<0.01),VD与NDCVD组相比叶酸水平不同(P<0.01),而Vitamin B_(12)水平无差别(P>0.05)。3组MMSE值VD组最低(16.05±5.94),各组之间明显不同(P<0.01)。初步显示补充叶酸、Vita- min B_(12)对VD患者认知功能有一定的改善作用。结论VD患者血清叶酸、Vitamin B_(12)水平明显低于健康者,低水平叶酸、Vitamin B_(12)可能对VD的认知功能有影响。
Objective The serum folie acid and Vitamin B12were determined in patients of vascular dementia （VD） ,non dementia eerebrovascular disease（NDCVD） and the healthy senile. Cognitive status was evaluated by using mini mental state examination （MMSE）. The effect of folie acid and Vitamin B12on VD and its cognitive func- tion were analyzed. Methods 80 patients were selected. Group distributions：VD（40）and NDCVD（40）. Forty healthy senile were selected at random as the control group. The patients were evaluated by MMSE and folie acid and Vitamin B12were determined. Result Serum foliate and Vitamin B12levels in VD group were lowest in the three groups. The median and 95% CI were 4.20ng/ml （4.07～5.50）,343.67pg/ml（296.54～413.73）. There was significant difference in VD compared with the control group（P〈0.01）,same difference of serum folie acid in VD comparing with NDCVD（P〈0.01） ,and no difference of serum Vitamin B12was found in VD and the NDCVD（P〉 0.05）. Scores of M MSE in VI）（ 16.05 ± 5.94）were significantly higher than NDCVD and the control group. There was striking difference in three groups（P〈0.01）. Supplement of folie acid and Vitamin B12possibly improve VD patients＇cognitive function. Conclusion Serum folie acid and Vitamin B12 level in VD were significantly lower in the three groups. Folie acid and Vitamin B12of low concentration are possible risk factors on VD and it＇s cognition.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2007年第6期719-722,共4页
Journal of Apoplexy and Nervous Diseases
